Results 71 to 80 of about 906,488 (387)

ACE‐mediated Glycosylation Stabilizes PSAP To Promote GPR37‐dependent Macrophage‐Nucleus Pulposus Cells Crosstalk and TGFβ Signaling in Alleviating Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ACE can modulate the CBL‐mediated K48 ubiquitination degradation of PSAP by altering its glycosylation levels in NP cells. As a result, NP cells secrete PSAP, which interacts with GPR37 on macrophage surfaces, facilitating their polarization toward the M2 phenotype. These M2 macrophages subsequently secrete TGFβ, which exerts feedback effects on the NP
Youfeng Guo, Feng Wang, Bijun Wang, Yu Zhou, Chao Wang, Tao Hu, Desheng Wu   +6 more
wiley   +1 more source

Computer-assisted radiographic calculation of spinal curvature in brachycephalic "screw-Tailed" dog breeds with congenital thoracic vertebral malformations: reliability and clinical evaluation [PDF]

, 2014
The objectives of this study were: To investigate computer-assisted digital radiographic measurement of Cobb angles in dogs with congenital thoracic vertebral malformations, to determine its intra- and inter-observer reliability and its association with ...
Faller, Kiterie, Guevar, Julien, Gutierrez Quintana, Rodrigo, Penderis, Jacques, Stalin, Catherine, Yeamans, Carmen   +5 more
core   +9 more sources

Comparative Clinical Effectiveness of Nonsurgical Treatment Methods in Patients With Lumbar Spinal Stenosis

JAMA Network Open, 2019
This randomized clinical trial compares the effectiveness of medical care, group exercise, and manual therapy/individualized exercise in patients with lumbar spinal stenosis (LSS).
Michael J. Schneider, C. Ammendolia, D. Murphy, R. Glick, E. Hile, Dana L. Tudorascu, S. Morton, Clair N. Smith, C. Patterson, S. Piva   +9 more
semanticscholar   +1 more source

Anti‐Swelling Hydrogel Combined With Nucleus Pulposus Cell Exosomes and Senolytic Drugs Efficiently Repair Intervertebral Disc Degeneration

Advanced Science, EarlyView.
In this study, a bifunctional anti‐swelling hydrogel system is developed, which encapsulated anti‐senescence drugs quercetin, dasatinib, nucleus pulposus‐derived exosomes (NP‐Exo) to clear senescent nucleus pulposus cells, regulate the inflammatory disc microenvironment, and enhance nucleus pulposus cells activity, ultimately promoting the repair of ...
Songfeng Chen, Hao Han, Yuhao Zhang, Longyu Li, Zhishuo Wang, Jiaming Zhang, Liang Han, Hongwei Kou, Guowei Shang, Chunfeng Shang, Zikuan Leng, Keya Mao, Chengwei Li, Lin Jin, Hongjian Liu   +14 more
wiley   +1 more source

Clinical evaluative value of cervical magnetic resonance T2 axial image in the severity of cervical canal stenosis

Zhongguo linchuang yanjiu
Objective To explore the clinical value of cervical magnetic resonance T2 axial image in evaluating thedegree of cervical canal stenosis，in order to guide precise clinical diagnosis and treatment.
FEI Changjun*，CHEN Bing，XIA Shiyong，ZHANG Xiaoyong，XIA Yiqiu，LI Hongxia
doaj   +1 more source

Antioxidant Carbon Dot of Selenomethionine Alleviates Oxidative Stress in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A selenomethionine‐derived carbon dot (Se‐Met‐CD) serves as a potent nano‐antioxidant, efficiently scavenging reactive oxygen species, protecting nucleus pulposus cells from oxidative damage, restoring extracellular matrix homeostasis, and significantly mitigating intervertebral disc degeneration in vivo, which demonstrates great promise as a nanozyme ...
Qingzheng Zhang, Zongtai Liu, Yirong Sun, Changfeng Fu, Jianxun Ding   +4 more
wiley   +1 more source

Endoscopic decompression for lumbar spinal canal stenosis: A technical note

Journal of Spinal Surgery, 2022
Laminectomy and fusion were surgical options to decompress neural structures and provide more space for the spinal cord in a stenosis patient with severe leg pain and progressive neurologic signs, such as numbness and weakness.
Kangtaek Lim, Jayesh Sardhara
doaj   +1 more source

Total body bone mineral density and various spinal disorders: a Mendelian randomization study

Frontiers in Endocrinology, 2023
IntroductionObservational studies have yielded inconsistent findings regarding the correlation between bone mineral density (BMD) and various spinal disorders.
Qingyu Jiang, Qingyu Jiang, Haihao Gao, Haihao Gao, Xudong Shi, Yan Wu, Wentao Ni, Aijia Shang   +7 more
doaj   +1 more source

Biportal Endoscopic Spinal Surgery for Lumbar Spinal Stenosis

Asian Spine Journal, 2019
Biportal endoscopic spinal surgery (BESS) is a minimally invasive spinal surgery, which is basically similar to microscopic spinal surgery in terms of the use of floating technique and technically similar to conventional percutaneous endoscopic spinal ...
Ju-Eun Kim, Dae-Jung Choi, E. Park, Ho-jin Lee, Jin-Ho Hwang, Moon-chan Kim, Jong-Seok Oh   +6 more
semanticscholar   +1 more source

Further Evidence That Chondrocalcinosis 1 (CCAL1) is a Confirmed Mendelian Phenotype With a Known Molecular Basis

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Chondrocalcinosis (CCAL), also known as calcium pyrophosphate dihydrate deposition disease (CPPDD), is a frequent multifactorial condition in the elderly, but there are two rare autosomal dominant Mendelian forms, CCAL1 (OMIM %600668) and CCAL2. Only three families with molecularly proven CCAL1 have been reported.
Anna‐Christina Pansa, Mareike Selig, Markus Wingendorf, Matthew A. Brown, Oliver Bartsch   +4 more
wiley   +1 more source