Results 281 to 290 of about 1,059,853 (352)

Accuracy and effectiveness of thoracolumbar pedicle screw placement with a mixed reality head mounted device: first clinical experience and results. [PDF]

Brain Spine
Reyes Medina B, Khafaji F, Saffour S, Sippl C, Linsler S.   +4 more
europepmc   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Response to the Letter to the Editor on "Role of Prophylactic Negative Pressure Wound Therapy in Reducing Surgical-Site Infections in Spine Surgery - A Systematic Review and Meta-Analysis". [PDF]

Global Spine J
Muthu S, Viswanathan VK, Kolarpatti Ponnusamy DV.   +2 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

A Closed-Loop Clinical Audit on Compliance With National Institute for Health and Care Excellence (NICE) Guidelines (NG232) for CT Cervical Spine Imaging in Adult Head Injury Patients. [PDF]

Cureus
Aslam I, Abbas T, Mubashir J.
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Transient C5 Palsy After Full-Endoscopic Posterior Cervical Foraminotomy

Case Reports in Orthopedics
João Paulo Machado Bergamaschi, Ariel Falbel Lugão, Rangel Roberto de Assis, Kelsen de Oliveira Teixeira, Fernando Flores de Araújo, Thiago Queiroz Soares, Gustavo Vitelli Depieri, Álvaro Dowling, Robson Cruz de Oliveira, Fernanda Wirth, Fábio da Silva Forti, Helton Luiz Aparecido Defino   +11 more
doaj   +1 more source

Occipitocervical dissociation: A narrative review and case series with a novel management algorithm proposal. [PDF]

J Craniovertebr Junction Spine
Cirillo I, Blanco S, Ricciardi G, Guiroy A, Carazzo C, Zamorano JJ, Fernandes JA.   +6 more
europepmc   +1 more source

Letter to Editor on "Sarcopenia as a Predictor of Mortality Following Vertebral Compression Fractures Treated With Vertebroplasty" by Hung-Kai Liao et al. [PDF]

Global Spine J
Perez-Abdala JI, Gonzalez-Viescas J, Perez-Corradini M.   +2 more
europepmc   +1 more source