Results 61 to 70 of about 151,054 (318)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

The Spin

open access: yesFortschritte der Physik, 2001
It is shown that the spin is naturally introduced into classical mechanics if the latter is formulated as dynamics of the phase space density. It is shown that the uncertainty principle, as the amendment in this dynamics, restricts possible spins, and in particular equation for the particle with the spin $\hbar /2$ is derived.
openaire   +4 more sources

Spin Accumulation with Spin-Orbit Interaction [PDF]

open access: yesPhysical Review Letters, 2009
Spin accumulation is a crucial but imprecise concept in spintronics. In metal-based spintronics it is characterized in terms of semiclassical distribution functions. In semiconductors with a strong spin-orbit coupling the spin accumulation is interpreted as a superposition of coherent eigenstates. Both views can be reconciled by taking into account the
Saarikoski, H. (author)   +1 more
openaire   +5 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Influence of Process Parameters on Forming Load of Variable-Section Thin-Walled Conical Parts in Spinning

open access: yesApplied Sciences, 2020
Thin-walled conical parts with variable-section are usually made of superalloy material, with poor plasticity and complex forces, which are difficult to form and control.
Yingxiang Xia   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Spinning-Driven Dynamic Nuclear Polarization with Optical Pumping

open access: yes, 2022
We propose a new, more efficient, and potentially cost effective, solid-state nuclear spin hyperpolarization method combining the cross-effect mechanism and electron spin optical hyperpolarization in rotating solids.
Krishnendu Kundu   +7 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Assessment the properties of various surgical sutures

open access: yesScientific Reports
The multiple disciplines such as materials science, engineering and biomedicine have facilitated the development of different types of surgical suture materials with multifunctionalities.
Doaa H. Elgohary   +4 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

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