Hyperglycemia disturbs trophoblast functions and subsequently leads to failure of uterine spiral artery remodeling [PDF]
Frontiers in Endocrinology, 2023 Uterine spiral artery remodeling is necessary for fetal growth and development as well as pregnancy outcomes. During remodeling, trophoblasts invade the arteries, replace the endothelium and disrupt the vascular smooth muscle, and are strictly regulated ...
Yueyue Zhu +4 more
doaj +2 more sources
VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development [PDF]
eLife, 2022 During formation of the mammalian placenta, trophoblasts invade the maternal decidua and remodel spiral arteries to bring maternal blood into the placenta.
Derek C Sung +13 more
doaj +2 more sources
Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia [PDF]
Frontiers in Cell and Developmental Biology, 2022 It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral
Heyam Hayder +5 more
doaj +2 more sources
Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling [PDF]
Redox Biology, 2022 The proteomic analysis from samples of patients with preeclampsia (PE) displayed a low level of ferritin light chains (FTL), but we do not know what the significance of reduced FTL in PE pathophysiology is. To address this question, we first demonstrated
Xiaofeng Yang +14 more
doaj +2 more sources
Pulsatile spiral blood flow through arterial stenosis [PDF]
Computer Methods in Biomechanics and Biomedical Engineering, 2014 Pulsatile spiral blood flow in a modelled three-dimensional arterial stenosis, with a 75% cross-sectional area reduction, is investigated by using numerical fluid dynamics.
Hyde, M.A., Linge, F., Paul, M.C.
core +4 more sources
Spiral Vein Graft Technique for Popliteal Artery AneurysmsWhat unique educational message is provided and why is it relevant? [PDF]
EJVES Short Reports, 2019 Introduction: In patients with popliteal artery aneurysm lacking a suitable vein for bypass, prosthetic graft, or endovascular stent graft are alternative treatment options. However, durability is limited.
Gustav Pedersen +3 more
doaj +3 more sources
Color Doppler ultrasound of spiral artery blood flow in mid first trimester (4–8 weeks) in cases of threatened abortion and in normal pregnancies [PDF]
Journal of Ultrasonography, 2019 Introduction: The aim of the study was to evaluate and compare the spiral artery flow in mid first trimester (4–8 weeks) in cases of threatened abortion and in normal pregnancies.
Rohit Bhoil +6 more
doaj +2 more sources
Differences in lymphocyte subsets of spiral artery associated with impaired vascular remodeling in hypertensive disorders of pregnancy [PDF]
BMC Pregnancy and ChildbirthHypertensive disorders of pregnancy (HDP) is assumed to be triggered by incomplete remodeling of the decidual spiral arteries. We examined the lymphocyte subsets and identified immune differences in the spiral arteries between HDP and normal pregnancies,
Ayako Tateishi +4 more
doaj +2 more sources
Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis [PDF]
BMC Medicine, 2023 Background Pre-eclampsia (PE) is one of the leading causes of maternal and fetal morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with inflammatory signaling; however, the pathophysiological mechanism by which A2M is ...
Jingyun Wang +13 more
doaj +2 more sources
Regulation of Uterine Spiral Artery Remodeling: a Review. [PDF]
Reprod Sci, 2020 AbstractExtravillous trophoblast remodeling of the uterine spiral arteries is essential for promoting blood flow to the placenta and fetal development, but little is known about the regulation of this process. A defect in spiral artery remodeling underpins adverse conditions of human pregnancy, notably early-onset preeclampsia and fetal growth ...
Albrecht ED, Pepe GJ.
europepmc +4 more sources