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Regulation of Uterine Spiral Artery Remodeling: a Review [PDF]
Reproductive Sciences, 2020 AbstractExtravillous trophoblast remodeling of the uterine spiral arteries is essential for promoting blood flow to the placenta and fetal development, but little is known about the regulation of this process. A defect in spiral artery remodeling underpins adverse conditions of human pregnancy, notably early-onset preeclampsia and fetal growth ...
Eugene D. Albrecht, Gerald J. Pepe
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Understanding the uterine artery Doppler waveform and its relationship to spiral artery remodelling [PDF]
Placenta, 2021 Analysis of the uterine artery (UtA) Doppler waveform is frequently used in high-risk pregnancies to assess the likelihood of adverse pregnancy outcomes, including preeclampsia and fetal growth restriction. Whilst abnormal UtA waveforms at 18-20 weeks are associated with adverse outcomes, the underlying cause of these waveform changes remains unknown ...
Lloyd-Davies, Claire +2 more
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Uterine spiral artery muscle dedifferentiation
Human Reproduction, 2019 AbstractSTUDY QUESTIONIs vascular smooth muscle cell (VSMC) dedifferentiation a feature of uterine spiral artery (SpA) remodelling in early human pregnancy?SUMMARY ANSWERRemodelling of human uterine SpAs is associated with dedifferentiation of VSMCs and can be induced in vitro by uterine natural killer (uNK) cells and extravillous trophoblast cells ...
Stephen C. Robson +7 more
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Spiral Artery Remodeling in Pregnancy [PDF]
Open Access Journal of Translational Medicine & Research, 2017 Brosen et al. suggested that the “physiological change” of spiral arteries in the pregnant uteri was a result of the destructive action of invading trophoblast on vascular smooth muscles and elastic membranes [5]. Later, a maternal contribution had to be
Nidhi Sharma
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Spiral Artery Remodeling in Preeclampsia Revisited [PDF]
Hypertension, 2013 See related article, pp 1046–1054 The first observations that placental bed defects were potentially linked to clinical outcomes such as preeclampsia (PE) were made nearly 50 years ago.1 This study followed prior findings that the placental clearance of radiolabeled saline was significantly decreased in women with hypertensive gestations.2 ...
S. Ananth Karumanchi, Suzanne D. Burke
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Cells, 2023 Estrogens, mainly 17β-estradiol (E2), play a critical role in reproductive organogenesis, ovulation, and fertility via estrogen receptors. E2 is also a well-known regulator of utero-placental vascular development and blood-flow dynamics throughout ...
M. Rusidzé +8 more
semanticscholar +1 more source
Frontiers in Endocrinology, 2023 Uterine spiral artery remodeling is necessary for fetal growth and development as well as pregnancy outcomes. During remodeling, trophoblasts invade the arteries, replace the endothelium and disrupt the vascular smooth muscle, and are strictly regulated ...
Yueyue Zhu +3 more
semanticscholar +1 more source
BMC Medicine, 2023 Background Pre-eclampsia (PE) is one of the leading causes of maternal and fetal morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with inflammatory signaling; however, the pathophysiological mechanism by which A2M is ...
Jingyun Wang +13 more
semanticscholar +1 more source
Modeling Trophoblast Cell-Guided Uterine Spiral Artery Transformation in the Rat
International Journal of Molecular Sciences, 2022 The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-guided uterine spiral artery remodeling, which resembles human placentation.
V. Shukla, M. Soares
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2022 It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral
Heyam Hayder +4 more
semanticscholar +1 more source