VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development [PDF]
eLife, 2022 During formation of the mammalian placenta, trophoblasts invade the maternal decidua and remodel spiral arteries to bring maternal blood into the placenta.
Derek C. Sung +13 more
semanticscholar +4 more sources
Color Doppler ultrasound of spiral artery blood flow in mid first trimester (4–8 weeks) in cases of threatened abortion and in normal pregnancies [PDF]
Journal of Ultrasonography, 2019 Introduction: The aim of the study was to evaluate and compare the spiral artery flow in mid first trimester (4–8 weeks) in cases of threatened abortion and in normal pregnancies.
R. Bhoil +6 more
semanticscholar +4 more sources
Decidual Vasculopathy in Preeclampsia and Spiral Artery Remodeling Revisited: Shallow Invasion versus Failure of Involution [PDF]
American Journal of Perinatology Reports, 2018 Decidual vasculopathy is commonly associated with preeclampsia and develops in the late pregnancy in the uterine spiral arteries, which were previously remodeled by the extravillous trophoblasts.
Peilin Zhang
semanticscholar +4 more sources
Spiral artery blood flow during pregnancy: a systematic review and meta-analysis [PDF]
BMC Pregnancy and Childbirth, 2019 Background Downstream remodeling of the spiral arteries (SpA) decreases utero-placental resistance drastically, allowing sustained and increased blood flow to the placenta under all circumstances.
V. Schiffer +5 more
semanticscholar +4 more sources
B‐flow/spatiotemporal image correlation M‐mode: novel ultrasound method that detects decrease in spiral artery luminal diameter in first trimester in primate model of impaired spiral artery remodeling [PDF]
Ultrasound Obstet Gynecol, 2021 To determine if B‐flow/spatiotemporal image correlation (STIC) M‐mode ultrasonography detects a decrease in spiral artery luminal diameter and volume flow during the first trimester in a non‐human primate model of impaired spiral artery remodeling (SAR).
O. Turan +6 more
semanticscholar +2 more sources
Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling [PDF]
Redox Biology, 2022 The proteomic analysis from samples of patients with preeclampsia (PE) displayed a low level of ferritin light chains (FTL), but we do not know what the significance of reduced FTL in PE pathophysiology is. To address this question, we first demonstrated
Xiaofeng Yang +14 more
doaj +2 more sources
Atrial natriuretic peptide promotes uterine decidualization and a TRAIL-dependent mechanism in spiral artery remodeling. [PDF]
J Clin Invest, 2021 Atrial natriuretic peptide (ANP) is an important hormone in cardiovascular biology. It is activated by the protease corin. In pregnancy, ANP and corin promote uterine spiral artery remodeling, but the underlying mechanism remains unknown.
Wei Zhang +6 more
semanticscholar +2 more sources
Overexpression of miR-210-3p Impairs Extravillous Trophoblast Functions Associated with Uterine Spiral Artery Remodeling [PDF]
Int J Mol Sci, 2021 Hsa-miR-210-3p has been reported to be upregulated in preeclampsia (PE); however, the functions of miR-210-3p in placental development are not fully understood, and, consequently, miR-210-3p’s role in the pathogenesis of PE is still under investigation ...
Heyam Hayder +5 more
semanticscholar +2 more sources
Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis [PDF]
Front Cell Dev Biol, 2021 Impaired invasion of extravillous trophoblasts and severe oxidative stress manifest the poor placentation in preeclampsia, which is life-threatening and more than a hypertensive disease of pregnancy.
Z. Lv +9 more
semanticscholar +2 more sources
Differences in lymphocyte subsets of spiral artery associated with impaired vascular remodeling in hypertensive disorders of pregnancy [PDF]
BMC Pregnancy and ChildbirthHypertensive disorders of pregnancy (HDP) is assumed to be triggered by incomplete remodeling of the decidual spiral arteries. We examined the lymphocyte subsets and identified immune differences in the spiral arteries between HDP and normal pregnancies,
Ayako Tateishi +4 more
doaj +2 more sources