Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy [PDF]
Proc Natl Acad Sci U S A, 2020 Significance In pregnancy, blood vessels in the uterus increase in size, providing more blood supply and nutrients to the growing fetus. Corin is an enzyme that boosts this process.
Can Wang +12 more
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Investigation of spiral blood flow in a model of arterial stenosis [PDF]
Medical Engineering & Physics, 2009 The spiral component of blood flow has both beneficial and detrimental effects in human circulatory system [Stonebridge PA, Brophy CM. Spiral laminar flow in arteries? Lancet 1991; 338: 1360-1]. We investigate the effects of the spiral blood flow in a model of three-dimensional arterial stenosis with a 75% cross-sectional area reduction at the centre ...
Paul, M.C., Larman, A.
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Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1 [PDF]
Scientific Reports, 2022 Impaired spiral artery remodeling (IRSA) underpins the great obstetrical syndromes. We previously demonstrated that intrauterine infection with the periodontal pathogen, Porphyromonas gingivalis, induces IRSA in rats.
Tanvi Tavarna +3 more
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Pulsatile spiral blood flow through arterial stenosis [PDF]
Computer Methods in Biomechanics and Biomedical Engineering, 2013 Pulsatile spiral blood flow in a modelled three-dimensional arterial stenosis, with a 75% cross-sectional area reduction, is investigated by using numerical fluid dynamics. Two-equation k-ω model is used for the simulation of the transitional flow with Reynolds numbers 500 and 1000. It is found that the spiral component increases the static pressure in
Linge, F., Hyde, M.A., Paul, M.C.
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Leukemia Inhibitory Factor (LIF) Inhibition during Mid-Gestation Impairs Trophoblast Invasion and Spiral Artery Remodelling during Pregnancy in Mice [PDF]
PLoS ONE, 2015 The placenta forms the interface between the maternal and fetal circulation and is critical for the establishment of a healthy pregnancy. Trophoblast cell proliferation, migration and invasion into the endometrium are fundamental events in the initiation
A. Winship +4 more
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Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling. [PDF]
J Clin Invest, 2019 Molecular heterogeneity of endothelial cells underlies their highly-specialized functions during changing physiological conditions within diverse vascular beds.
J. B. Pawlak +10 more
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Doppler Evaluation of Uterine Blood Flow in Patients with Unexplained Recurrent Pregnancy Loss [PDF]
International Journal of Women's HealthYanyu Zhong,1,* Nan Wang,1,* Sihui Lu,2 Yaqian Lu,2 Xin Pan,3 Ying Zhou1 1Reproductive Medicine Centre, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Obstetrics and Gynecology, The Fourth ...
Zhong Y +5 more
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MicroRNA‐590‐3p inhibits trophoblast‐dependent maternal spiral artery remodeling by repressing low‐density lipoprotein receptor‐related protein 6 [PDF]
Mol Genet Genomic Med, 2018 The remodeling of maternal spiral artery following embryo implantation, which relies on well‐regulated trophoblast functions, is a pivotal process to ensure a successful pregnancy.
Yinghong Zhang +5 more
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Bisphenol A exposure during early pregnancy impairs uterine spiral artery remodeling and provokes intrauterine growth restriction in mice [PDF]
Sci Rep, 2018 Endocrine disrupting chemicals are long suspected to impair reproductive health. Bisphenol A (BPA) has estrogenic activity and therefore the capacity of interfering with endocrine pathways.
Judith Müller +7 more
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Decidual natural killer cells regulate vessel stability: implications for impaired spiral artery remodelling [PDF]
Journal of Reproductive Immunology, 2015 Decidual NK (dNK) cells are present during uterine spiral artery remodelling, an event that is crucial for successful placentation and the provision of an adequate blood supply to the developing fetus.
R. Fraser +3 more
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