Results 41 to 50 of about 29,747 (298)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Screening for Action Tremor in Epidemiological Field Surveys: Assessing the Reliability of a Semi-Quantitative, Visual, Template-Based Scale for Rating Hand-Drawn Spirals

Tremor and Other Hyperkinetic Movements, 2012
Background: Population-based epidemiological studies of essential and other tremors have need of a rapid yet accurate means to assess tremor, especially mild tremors.
Elan D. Louis, Qianhua Zhao, Haijiao Meng, Ding Ding   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Lateral cyclic behavior of bridge columns confined with pre-stressed shape memory alloy wires

Journal of Asian Architecture and Building Engineering, 2022
This study focuses on investigating the effects of the wrapping mode of shape memory alloy (SMA) spirals with a large pre-strain on the lateral cyclic behavior of the bridge columns.
Shengshan Pan, Rui Yue, Huaxing Hui, Shuli Fan   +3 more
doaj   +1 more source

Downward spirals to vulnerability

Journal of Comparative Social Work, 2021
One of the most frequently voiced concerns in the wake of the COVID-19 pandemic is ‘not to forget the vulnerable groups in society’. Social workers occupy a privileged position with a view to mapping such vulnerabilities, their complex interrelations ...
Bart Put, Kim Bastaits, Inge Pasteels, Michiel Massart   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Phase spirals induced by the gas warp

Astronomy & Astrophysics
Context. The discovery of the phase space-spirals in the Solar neighborhood in Gaia Data Release 2 has prompted various attempts to understand their origin. A source of bending waves that has been neglected as a cause of the phase spiral is irregular gas
Wang Shuyu, Brown Anthony G. A., Debattista Victor P., Khachaturyants Tigran   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Striatonigrostriatal Spirals in Addiction

Frontiers in Neural Circuits, 2021
A biological reward system is integral to all animal life and humans are no exception. For millennia individuals have investigated this system and its influences on human behavior.
Andy Sivils, John Q. Wang, Xiang-Ping Chu   +2 more
doaj   +1 more source