Results 81 to 90 of about 29,747 (298)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Why Are Some Optically Red Spirals Near-ultraviolet− r Blue?
The Astrophysical JournalTo understand the complicated formation processes of disk galaxies, we carry out a comparative study of near-ultraviolet (NUV)− r blue and red spiral galaxies drawn from a parent sample of u−r red spirals with M _* > 10 ^10.5 M _⊙ at 0.02
Rui Guo +4 more
doaj +1 more source
Physics Letters B, 2015 We propose a novel scenario of primordial inflation in which the inflaton goes through a spiral motion starting from around the top of a symmetry breaking potential. We show that, even though inflation takes place for a field value much smaller than Planck scale, it is possible to obtain relatively large tensor to scalar ratio ($r \sim 0.1$) without ...
Barenboim, Gabriela, Park, Wan-Il
openaire +4 more sources
A note on spirals and curvature
, 2020 : Starting from logarithmic, sinusoidal and power spirals, it is shown how these spirals are connected directly with Chebyshev polynomials, Lam\ue9 curves, with allometry and Antonelli-metrics in Finsler geometry.
Shi, Peijian +3 more
core +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Electronic Workshops in Computing, 2015 This early version of Sound Spirals used field recorded soundscapes of human voices, physical actions such as walking on gravel paths and insect sounds as material for computational, digitally-fabricated sculptures. The sculptures share some similarity in process with Andy Huntington’s Sound Cylinder and Luke Jerram’s data sculpture but used different ...
openaire +2 more sources
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Experimental Mathematics, 2013 We introduce a geometric construction which relates to the pentagram map much in the way that a logarithmic spiral relates to a circle. After introducing the construction, we establish some basic geometric facts about it, and speculate on some of the deeper algebraic structure, such as the complete integrability of the associated dynamical system.
openaire +2 more sources