Results 51 to 60 of about 9,016 (243)

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Companionship in the spirit. A history of the spirituality of the Society of Jesus

Estudios Eclesiásticos, 2016
One of the most unique features of Ignatian Spirituality is the development of a loving gaze on all things, on all Creation, starting with a merciful and unconditional acceptance of the person who prays. «God labors and works for me in all creatures» [Sp
José García de Castro Valdés, SJ
doaj  

The persona of the early modern philosopher

Lychnos
This article provides a critical assessment of the scholarly analysis of the persona of the early modern philosopher. In particular, it examines the ways in which historians have tended to analyse the formation of philosophical personhoods in terms of ...
Andreas Rydberg
doaj   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

To Know Is To Be – Wisdom in Philosophy as a Way of Life and Its Implications for our Understanding of Knowledge

Eidos. A Journal for Philosophy of Culture
In my paper, I attempt to show how the Hadotian metaphilosophical perspective of philosophy as a way of life (PWL for short) implies another conception of what true, philosophical knowledge is: a conception that one should understand through Hadot’s ...
Lucas Nascimento Machado
doaj   +1 more source

Dilute but Dense – Reversible Crosslinking Enables Water‐Rich (Bio)polymer Condensates

Advanced Science, EarlyView.
Reversible crosslinking between two types of (bio)polymers drives liquid–liquid phase separation even in good solvent. The arrangement of binding motifs controls condensate formation and density, and internal network structure. Simulations and theory reveal a closed‐loop coexistence phase diagram at very low monomer concentrations and re‐entrant ...
Xinxiang Chen, Jude Ann Vishnu, Pol Besenius, Julian König, Friederike Schmid   +4 more
wiley   +1 more source

Philosophical Dogmas or Questions? A Defense of Philosophical Questioning as a Way of Life

Eidos. A Journal for Philosophy of Culture
This article compares two different ways of construing philosophy as a way of life (PWL), examining how they influence our understanding of the philosophical tradition and of philosophy today.
Hélder Telo
doaj   +1 more source

La Iglesia de San Ignacio de Santafé de Bogotá: Una puesta en escena para la educación de los sentidos (siglos XVII y XVIII)

Grafía, 2015
During the 17th and 18th centuries, the first Jesuitical temple in Santafé de Bogotá was the San Ignacios´s one. It was a true educational center more than cultic place and it attracted people of all social classes, assembled in religious congregations ...
Sandra Páez Álvarez
doaj   +1 more source

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source