Results 31 to 40 of about 4,327,403 (289)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

SPIRITUALITAS CALVIN SEBAGAI SPIRITUAL FORMATION MAHASISWA TEOLOGI

Manna Rafflesia, 2020
Students in theology schools must have a clear and determined calling. Often this commitment fades because the knowledge of God only happens in the mind, not in the heart. Therefore we need teaching that can invite them back to deepen their commitment to
Obet Nego
doaj   +1 more source

Training Integrated Clinicians by Example: A Practical Call for Ongoing Spiritual Formation and Mentoring amongst Christian Integrative Counseling Faculty

Religions, 2023
The body of literature on the integration of Christianity and psychology and/or counseling indicates that integration is best learned and taught through spiritual formation and mentoring relationships.
Haley R. French
doaj   +1 more source

Spiritual Formation: Challenges and Coping Mechanisms of Senior High Seminarians in the New Normal Education [PDF]

, 2023
The education sector is one of the highly affected by the COVID- 19 pandemic. In the Philippines, various measures have been initiated to implement social isolation strategies, and online teaching is followed with rapid curriculum transformation.
Maria Aurora G. Victoriano, Lodecy V. Ocbena, Kent Ian V. Ocbena, John Dave Eballa   +3 more
core   +1 more source

Understanding the Burden of Orofacial Involvement and Patient Treatment Preferences in Systemic Sclerosis: Results From a Large International Survey

Arthritis Care &Research, EarlyView.
Objective Orofacial manifestations are significantly impactful in patients with systemic sclerosis (SSc) yet remain understudied, with no dedicated clinical guidelines to inform their management. Methods An international online survey comprised38 questions addressing orofacial manifestations of SSc, including patients’ confidence in their treating ...
Eleni Deligianni, Lee Shapiro, Deana Gibbs, Zsuzsanna H. McMahan, Michael Hughes   +4 more
wiley   +1 more source

Formation Experiences of First-Year Students at a Progressive Christian Seminary: A Longitudinal Qualitative Study

Religions
This study explored the question, “How are seminary students’ formation experiences shaped over their first year in seminary?” Research questions and goals were formulated through a collaborative practical theology approach with seminary leaders.
Kristen R. Hydinger, Starla J. Gooch, Steven J. Sandage, Sarah A. Crabtree   +3 more
doaj   +1 more source

Mission-minded pastoral theology and the notion of God’s power: Maturity through vulnerability

In die Skriflig, 2023
This article contributed to constructive missional theology by grappling with the issues of God’s power and Christian maturity. This is important, because we live in a wounded world fraught with injustice, violations of human dignity, and power abuse ...
Stéphan van der Watt
doaj   +1 more source

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

African and Western approaches to the moral formation of Christian leaders: The role of spiritual disciplines in counteracting moral deficiencies

HTS Teologiese Studies/Theological Studies, 2020
This article begins with a brief outline of current African and Western contexts, and the moral predicaments in which leaders in South Africa find themselves.
Louise Kretzschmar
doaj   +1 more source