Results 31 to 40 of about 886,690 (287)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Multi-criteria Evaluation of the State of Professional Theatres in the Czech Republic in Terms of Mixed Public Goods Provided to the Citizens

open access: yesReview of Economic Perspectives, 2018
The provision of public goods is an important aspect of public sector management, and it is a subject of specific conditions. Public Goods should be provided efficiently and in accordance to consumer demand and should meet the provider's political and ...
Ardielli Eva, Bečica Jiří
doaj   +1 more source

Dobra materialne w służbie człowiekowi – teologiczna interpretacja funkcji gospodarczej rodziny

open access: yesStudia Warmińskie, 2011
Exercising the economic function of the family manifests itself in making use of material goods in such a way that they serve the best possible way the permanent effort of an individual to self-improve.
Janusz Szulist
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

open access: yesArthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Administration of Ecclesiastical Temporal Goods in the Light of the Instructions of the Polish Episcopal Conference of 2015

open access: yesThe Person and the Challenges, 2017
The mission of the Church is evangelisation and not acquisition of capital. It is good if the Church has sufficient financial means necessary to fulfil its mission.
Robert Kantor
doaj   +1 more source

Understanding the Burden of Orofacial Involvement and Patient Treatment Preferences in Systemic Sclerosis: Results From a Large International Survey

open access: yesArthritis Care &Research, EarlyView.
Objective Orofacial manifestations are significantly impactful in patients with systemic sclerosis (SSc) yet remain understudied, with no dedicated clinical guidelines to inform their management. Methods An international online survey comprised38 questions addressing orofacial manifestations of SSc, including patients’ confidence in their treating ...
Eleni Deligianni   +4 more
wiley   +1 more source

Clinician and Patient Factors Associated With Long‐Term Glucocorticoid Use in People With Rheumatoid Arthritis Receiving Advanced Therapies

open access: yesArthritis Care &Research, EarlyView.
Objective Despite guideline recommendations, long‐term glucocorticoid (GC) use is common in rheumatoid arthritis (RA). We conducted a clinician survey nested within a large registry to identify patient and clinician factors associated with GC use. Methods Clinicians contributing patients to the CorEvitas Rheumatoid Arthritis Registry were surveyed ...
Michael D. George   +7 more
wiley   +1 more source

The Baron, his niece and friends : Friedrich von Hügel as a spiritual director, 1915-1925 [PDF]

open access: yes, 2013
While the practice of spiritual direction is widespread and increasingly popular, there has been relatively little research on the practices of those perceived to be exemplary spiritual directors. The primary focus of this dissertation is Baron Friedrich
Wrigley-Carr, Robyn
core   +2 more sources

LOS OBISPOS DE LA PROVINCIA ECLESIÁSTICA DE ECUADOR Y LA CODIFICACIÓN DEL DERECHO CANÓNICO DE 1917: LOS "POSTULATA EPISCOPORUM" ACERCA DE LOS BIENES ESPIRITUALES Y TEMPORALES BlSHOPS CHURCH OF THE PROVINCE OF ECUADOR AND THE CODIFICATION OF CANON LAW OF 1917: THE "POSTULATA EPISCOPORUM" ABOUT THE SPIRITUAL AND TEMPORAL GOODS

open access: yesRevista de Derecho (Coquimbo), 2011
La redacción del primer Código de Derecho Canónico que tuvo la Iglesia latina fue ordenada por el papa san Pío X en 1904. La tarea codificadora, empero, no fue obra de un grupo cerrado de expertos, sino que tuvo en cuenta el parecer del episcopado latino,
Carlos Salinas Araneda
doaj  

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