Results 81 to 90 of about 886,690 (287)

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

open access: yesAdvanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian   +13 more
wiley   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

open access: yesAdvanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang   +6 more
wiley   +1 more source

MODERN TENDENCIES OF TOURISTIC DEMAND

open access: yesAdvanced Engineering Research, 2009
Tourism as a kind of activity is directed for rendering of various kinds of services and goods of touristic demand by touristic enterprises for the purpose of assisting satisfaction of various cultural, spiritual, cognitive and other touristic needs. The
I.V. POPOVA
doaj  

Philanthropy according to Saint Gregory Palamas

open access: yesPhilanthropia
Saint Gregory Palamas stresses the importance of philanthropy for spiritual life and harmonious social coexistence. God has revealed Himself to man as good and philanthropic, and therefore each person is called to imitate His philanthropy, which is not ...
Miltiadis Vantsos, Julianna Giannoutsou
doaj   +1 more source

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

open access: yesAdvanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho   +6 more
wiley   +1 more source

MODERN TENDENCIES OF TOURISTIC DEMAND

open access: yesВестник Донского государственного технического университета, 2018
Tourism as a kind of activity is directed for rendering of various kinds of services and goods of touristic demand by touristic enterprises for the purpose of assisting satisfaction of various cultural, spiritual, cognitive and other touristic needs. The
I.V. POPOVA
doaj  

The Role of Material Goods in Spiritual Development

open access: yesDialogue and Universalism, 1996
The problem of materialism is widely recognized as a source of dissatisfaction in industrial civilization. At the same time, mass production and modern technology are also acknowledged as providing desirable standards of health, education, and physical comfort.
openaire   +2 more sources

Defining and assessing spiritual health : a comparative study among 13- to 15-year-old pupils attending secular schools, Anglican schools, and private Christian schools in England and Wales [PDF]

open access: yes, 2012
This article argues that the nation's commitment to young people involves proper concern for their physical health, their psychological health, and their spiritual health.
Penny, Gemma   +5 more
core   +1 more source

A Large Scale Multi‐Modal Workflow for Battery Characterization: From Concept to Implementation

open access: yesAdvanced Energy Materials, EarlyView.
Isolated characterization techniques produce independent datasets and single‐property insights. However, progressively more holistic interpretations of battery‐material behavior is needed in the future. Here we demonstrate a coordinated multimodal workflow enabling the correlation of heterogeneous datasets and the construction of multidimensional ...
François Cadiou   +34 more
wiley   +1 more source

Temporal and Eternal Goods and the Idea of a Theistic Spirituality

open access: yesAGATHEOS – European Journal for Philosophy of Religion
In this paper, I consider two objections to the idea of a theistic spirituality, each grounded in a certain conception of eternity: the first maintains that on the relevant notion of eternity, theism issues in a degraded account of the significance of our lives in time, while the second proposes that on a further, related notion of eternity, theism ...
openaire   +2 more sources

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