Results 291 to 300 of about 3,016,957 (322)

Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.

Journal of Medicinal Chemistry, 2016
Scaffold modification based on Wang's pioneering MDM2-p53 inhibitors led to novel, chemically stable spiro-oxindole compounds bearing a spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one scaffold that are not prone to epimerization as observed for the initial ...
A. Gollner, D. Rudolph, Heribert Arnhof, Markus J. Bauer, Sophia M. Blake, G. Boehmelt, Xiao-Ling Cockroft, G. Dahmann, P. Ettmayer, Thomas Gerstberger, Jale Karolyi-Oezguer, D. Kessler, C. Kofink, J. Ramharter, J. Rinnenthal, A. Savchenko, R. Schnitzer, Harald Weinstabl, Ulrike Weyer-Czernilofsky, Tobias Wunberg, D. McConnell   +20 more
semanticscholar   +1 more source

Spiro Compounds for Organic Light-Emitting Diodes

Accounts of Materials Research, 2021
Yang‐Kun Qu, Qi Zheng, Jian Fan, L. Liao, Zuo‐Quan Jiang   +4 more
semanticscholar   +1 more source

Synthesis of spiro-oxoindoles through Pd-catalyzed remote C-H alkylation using α-diazocarbonyl compounds.

Chemical Communications, 2017
In this communication we describe a new route to spiro-oxoindole derivatives through a novel Pd-catalyzed cascade process. This reaction is based on the remote C-H activation performed by σ-alkyl Pd(ii) species generated in situ via intramolecular ...
M. Pérez-Gómez, Sergio Hernández-Ponte, D. Bautista, J. García‐López   +3 more
semanticscholar   +1 more source

Synthesis and Application of Chiral Spiro Cp Ligands in Rhodium-Catalyzed Asymmetric Oxidative Coupling of Biaryl Compounds with Alkenes.

Journal of the American Chemical Society, 2016
The vastly increasing application of chiral Cp ligands in asymmetric catalysis results in growing demand for novel chiral Cp ligands. Herein, we report a new class of chiral Cp ligands based on 1,1'-spirobiindane, a privileged scaffold for chiral ligands
Jun-Cheng Zheng, Wenquan Cui, C. Zheng, S. You   +3 more
semanticscholar   +1 more source

One-Pot, Catalyst-Free Synthesis of Spiro[dihydroquinoline-naphthofuranone] Compounds from Isatins in Water Triggered by Hydrogen Bonding Effects

, 2017
A one-pot, catalyst-free route to spiro[dihydroquinoline-naphthofuranone] compounds from isatins through ring-opening and cyclization processes in water is disclosed.
Dulin Kong, Guo-ping Lu, Mingshu Wu, Zaifeng Shi, Q. Lin   +4 more
semanticscholar   +1 more source

Spiro-compounds, synthesis and catalytic dehydrogenation of substituted spiro[5,5] undecanes

Tetrahedron, 1976
Abstract Catalytic dehydrogenation of 1-propyl-8,9-benzospiro[5,5]undecane-7-ol (5: R = H), and 1-propyl-3′-methyl-8,9-benzospiro[5,5]undecane-7-ol (5: R = Me) has been carried out to study the effect of a bulky alkyl group on the ring in the ring transformation of the spiro[5,5]undecane system. The catalytic dehydrogenation of the spiro-compound 5(R
M. Dutta Gupta, Ashutosh Mitra
openaire   +2 more sources

The Synthesis of Spiro[tetrahydroisoquinoline‐piperidines] and related compounds

Helvetica Chimica Acta, 1975
AbstractThe reaction of 3,4‐dimethoxyphenethylamine with some cyclic aminoketones in the presence of polyphosphoric acid afforded 1‐spiro‐tetrahydroisoquinolines. A two‐step procedure starting from veratrylamine and amino‐ketones gave 3‐spiro‐tetrahydroisoquinolin‐4‐ones.
Daniel Berney, Theodor Jauner
openaire   +3 more sources

Synthesis, characterization and pharmacological evaluation of novel spiro heterocyclic compounds as anti diabetic agents

, 2017
Natural products possessing a spiro carbon in their molecules have proven their biological activity in agriculture and medicine. The present paper describes the synthesis, characterization of five newly synthesized Spiro-compounds characterized by means ...
K. K. Kumar, R. Sharma, P. Babu, M. S. Rao, K. D. Prasadu, D. R. Kumar   +5 more
semanticscholar   +1 more source

Tunable Dimerization and Trimerization of β‐Alkynyl Ketones via Silver Catalysis for Accessing Spiro and Dispiro Compounds Containing 1H‐Isochromene

, 2017
New silver-catalyzed tunable dimerization and trimerization of β-alkynyl ketones have been established, enabling multiple C-C bond-forming events to selectively access skeletally diverse spiro isochromenes with generally good yields.
Daniel K. W. Wang, Shuainan Liu, Xin-Chan Lan, Armando Paniagua, Wen-Juan Hao, Guigen Li, S. Tu, Bo Jiang   +7 more
semanticscholar   +1 more source

Phosphorus–nitrogen compounds. Part 36. Syntheses, Langmuir–Blodgett thin films and biological activities of spiro-bino-spiro trimeric phosphazenes

, 2016
The condensation reactions of hexachlorocyclotriphosphazene (N3P3Cl6, trimer) with the symmetric N2N2 or N2O2 donor type tetradentate bulky ligands (1–4) gave partly substituted spiro-bino-spiro (sbs) (5–8) trimeric phosphazenes.
Nuran Asmafiliz, Z. Kılıç, M. Ci̇van, Orhan Avcı, L. Y. Gönder, L. Açık, B. Aydın, M. Türk, T. Hökelek   +8 more
semanticscholar   +1 more source