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The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration
Journal of NeurochemistryNumerous illnesses, including neurological and mental disorders, have been associated with mitochondrial dysfunction. Disruptions in mitochondrial respiration and energy production have been linked to dysmetabolism of the tryptophan (Trp)‐kynurenine (KYN)
László Juhász +17 more
semanticscholar +1 more source
Therapy-induced senescence is a transient drug resistance mechanism in breast cancer
Molecular CancerTherapy-induced senescence (TIS) is considered a permanent cell cycle arrest following DNA-damaging treatments; however, its irreversibility has recently been challenged.
Eszter Bajtai +15 more
semanticscholar +1 more source
The Future is Sparse: Embedding Compression for Scalable Retrieval in Recommender Systems
ACM Conference on Recommender SystemsIndustry-scale recommender systems face a core challenge: representing entities with high cardinality, such as users or items, using dense embeddings that must be accessible during both training and inference.
Petr Kasalický +5 more
semanticscholar +1 more source
What sets the mutation rate of a cell type in an animal species?
bioRxivGermline mutation rates per generation are strikingly similar across animals, despite vast differences in life histories. Analogously, in at least one somatic cell type, mutation rates at the end of lifespan are comparable across mammals.
Marc de Manuel +3 more
semanticscholar +1 more source
Pathology oncology research : POR
Photobleaching of immunofluorescence signal is a well-known phenomenon, however, its impact on derived parameters characterizing number and shape of different cell types in tissue sections is less understood. Our aim was to determine whether the duration
T. Polgár +8 more
semanticscholar +1 more source
Photobleaching of immunofluorescence signal is a well-known phenomenon, however, its impact on derived parameters characterizing number and shape of different cell types in tissue sections is less understood. Our aim was to determine whether the duration
T. Polgár +8 more
semanticscholar +1 more source
Czteroletnia przyjaźń Witolda Friemanna z Michałem Spisakiem (na podstawie listów)
Notes Muzyczny, 2022exaly