Results 241 to 250 of about 161,904 (296)

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Risk stratification in locally invasive pancreatic serous cystic neoplasms: systematic review and two cases. [PDF]

J Clin Pathol
Tan C, Chen X, Ni SJ, Zhang M, Cai X, Jiang W, Sheng W, Huang D.   +7 more
europepmc   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

Liver and Spleen Point Shear-Wave Elastography in Newly Diagnosed <i>BCR::ABL1</i>-Negative Myeloproliferative Neoplasms: Associations with Hematological Parameters and Bone Marrow Fibrosis Grade - A Prospective Cross-Sectional Study [PDF]

Turk J Haematol
Avcı MT, Cömert M, Kiper D, Kavukçu G, Dönmez A, Tamsel S, Hekimgil M, Özsan N, Özbek SS.   +8 more
europepmc   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Diffuse large B‑cell lymphoma followed by myelodysplastic syndrome with TP53 mutation: a case report and literature review. [PDF]

Front Oncol
Wu X, Zhao J, Fan Y, Yang X, Yang X.
europepmc   +1 more source

A case report of splenic malignancy originating from the liver. [PDF]

Front Oncol
Shen L, Xu Y, Li J, Yang Z.
europepmc   +1 more source

Docetaxel for recurrent adult granulosa cell tumor enabling tertiary cytoreduction. [PDF]

Gynecol Oncol Rep
Ali M, Chua KJC, Chen H.
europepmc   +1 more source

Dengue Fever Unmasking JAK2 Mutation-Related Polycythemia Vera Presenting With Extensive Splanchnic Venous Thrombosis and Hemorrhagic Complications: A Diagnostic and Therapeutic Challenge. [PDF]

Cureus
Ayesha R, Sikandar F, Sikandar NUA, Tabasum A.   +3 more
europepmc   +1 more source

Beyond the Bone Marrow: A Case Report of Extramedullary Hematopoiesis in Advanced Primary Myelofibrosis. [PDF]

Cureus
Grisales Cano DA, Castellanos Olarte WA, Londoño Fonseca AM, Bonilla Cardona NJ, Salas Fernandez S.   +4 more
europepmc   +1 more source