Results 41 to 50 of about 44,983 (288)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Right side splenorenal fusion with marked extramedullary hematopoiesis, a case report

Human Pathology: Case Reports, 2018
Developmental abnormalities of the spleen are common, much less common is splenic fusion abnormality. It may present as a renal mass sometimes with symptoms of hypersplenism (anemia) or as a renal mass only, mimicking primary or secondary renal neoplasms
Mahtab Rahbar, Sourena Mardanpour
doaj   +1 more source

Splenic hemangioendothelial neoplasm in a captive Northern Snakehead from the Potomac River

Journal of Aquatic Animal Health, 2023
Abstract Objective At the U.S. Geological Survey Leetown Research Laboratory in Kearneysville, West Virginia, an approximately 3-year-old, captive-held Northern Snakehead Channa argus with clinical signs of abdominal distention died and was necropsied 1 day after an examination under anesthesia.
Heather L. Walsh, Vicki S. Blazer, Jeffrey C. Wolf, Christine L. Densmore   +3 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Retrospective study of splenectomy specimens with clinical and pathological features in Southern Iran

Scientific Reports
The spleen is the target of numerous non-neoplastic and uncommon neoplastic lesions. Our study’s objective was to evaluate the main indications and clinicopathologic features of a large number of splenectomy specimens from southern Iran, with a focus on ...
Neda Soleimani, Mitra Soleimani, Firouze Jafari, Sahand Mohammadzadeh, Mehrdad Karajizadeh   +4 more
doaj   +1 more source

Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia

Haematologica, 2013
The BRAF-V600E mutation defines genetically hairy cell leukemia among B-cell leukemias and lymphomas. In solid tumors, BRAF-V600E is known to aberrantly activate the oncogenic MEK-ERK pathway, and targeted BRAF and/or MEK inhibitors have shown remarkable
Enrico Tiacci, Gianluca Schiavoni, Maria Paola Martelli, Emanuela Boveri, Roberta Pacini, Alessia Tabarrini, Silvia Zibellini, Alessia Santi, Valentina Pettirossi, Elisabetta Fortini, Stefano Ascani, Luca Arcaini, Giorgio Inghirami, Marco Paulli, Brunangelo Falini   +14 more
doaj   +1 more source

Asymptomatic Multiple Splenic Cysts in a Pulmonary Neoplasm Patient

Journal of Nippon Medical School, 2012
Splenic cysts are rare, and their treatment remains challenging. A 66-year-old man scheduled to undergo surgical treatment for a pulmonary neoplasm was found with abdominal computed tomography and ultrasonography to have multiple cysts in the body of the spleen. He underwent pulmonary wedge resection, and histological examination showed that the lesion
Yuan, Shi-Min, Lin, Jian-Sheng
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Splenic Vein Aneurysm Mimicking Endocrine Pancreatic Tumor. [PDF]

, 2013
Context Splenic vein aneurysm (SVA) is an extremely rare vascular abnormality, and is usually caused by portal hypertension. Symptoms are unusual, but may include rupture or abdominal pain.
Liessi, Guido, Liessi F., Dalla Bona E., Liessi G., PASQUALI, CLAUDIO, Beltrame V., Beltrame, Valentina, Liessi, Federica, Dalla Bona, Enrico, SPERTI, COSIMO   +9 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source