Results 41 to 50 of about 161,904 (296)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia

Haematologica, 2013
The BRAF-V600E mutation defines genetically hairy cell leukemia among B-cell leukemias and lymphomas. In solid tumors, BRAF-V600E is known to aberrantly activate the oncogenic MEK-ERK pathway, and targeted BRAF and/or MEK inhibitors have shown remarkable
Enrico Tiacci, Gianluca Schiavoni, Maria Paola Martelli, Emanuela Boveri, Roberta Pacini, Alessia Tabarrini, Silvia Zibellini, Alessia Santi, Valentina Pettirossi, Elisabetta Fortini, Stefano Ascani, Luca Arcaini, Giorgio Inghirami, Marco Paulli, Brunangelo Falini   +14 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Rare Coincidence of Gastric Cancer and Large Myofibroblastic Tumor of The Spleen

Acta Medica Bulgarica
Although its incidence has been decreasing during the last decades, gastric cancer remains a common disease and a global health problem. Conversely, inflammatory myofibroblastic tumors, especially the splenic ones, are extremely rare neoplasms.
Arabadzhieva E.
doaj   +1 more source

Isolated splenic sarcoidosis: A case report

Anales del Sistema Sanitario de Navarra
Isolated splenic sarcoidosis is a rare entity, but clinicians should consider it in patients with compatible clinical features. Its diagnosis is challenging due to the broad differential diagnosis, which includes hematologic and splenic neoplasms ...
Coro Velasco Gametxogoikoetxea, Irene Fernández De Los Reyes, Fermín Jiménez Bermejo   +2 more
doaj   +1 more source

Primary Angiosarcoma of the Spleen: An Oncological Enigma

Case Reports in Oncological Medicine, 2014
Introduction. Primary splenic angiosarcoma is an extremely unusual neoplasm originating from sinusoidal vascular endothelium. Surgical extirpation is the mainstay of treatment of this highly malignant disease. Case Presentation.
Myoteri Despoina, Dellaportas Dionysios, Ayiomamitis Georgios, Strigklis Konstantinos, Kouroumpas Efstratios, Zizi-Sermpetzoglou Adamantia   +5 more
doaj   +1 more source

Uncommon Presentations of Pancreatic Neoplasms, Rare Neoplasms, and Peripancreatic Masses

, 2022
Pancreatic masses with atypical radiological appearance are frequently encountered. Atypical presentation of common pancreatic tumor is also possible.
Antonia Olivieri, Roberto Calbi, Paola Capelli, Angela Calabrese, Paolo Tinazzi Martini, Nicolò Cardobi, Mirko D’Onofrio, Riccardo De Robertis, Luca Geraci   +8 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Atypical Presentation of Primary Splenic Diffuse Large B-cell Non-Hodgkin Lymphoma, CD30 Positive: Case Report

Iatreia
Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma; however, its primary splenic variant (DLBCL-PS) is unusual and can present atypical clinical manifestations.
Muñoz-Ramírez, Carlos Javier, Leyton-Luna, Eliana, Ruíz-López, Víctor Andrés   +2 more
doaj   +1 more source