Results 111 to 120 of about 26,808 (306)

Subcutaneous Splenosis of the Abdominal Wall: Report of a Case and Review of the Literature

Case Reports in Surgery, 2013
Splenosis is a common benign condition that occurs after splenic rupture via trauma or surgery. The mechanism behind splenic cell autotransplantation begins with the splenic rupture, either from trauma or surgical removal.
Evangelia Papakonstantinou, Vasileios Kalles, Ioannis Papapanagiotou, Theodoros Piperos, Dimitrios Karakaxas, Vasileios Bonatsos, Konstantinos Tsoumakas, Filotheos Orfanos, Theodoros Mariolis-Sapsakos   +8 more
doaj   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

گزارش يک مورد پارگی طحال بدون سابقه ضربه در خانم باردار در بيمارستان شهيد اکبرآباديRupture of the Spleen without any History of Trauma in a Pregnant Woman in Shahid Akbar Abadi Hospital: A Case Report [PDF]

, 2005
پارگی طحال در صورتی که سابقه ضربه وجود نداشته باشد شايع نيست ولی از لحاظ کلينيکی حايز اهميت است. اگر اين پارگی به موقع تشخيص داده نشود و درمان صورت نگيرد، با نتايج وخيمی همراه است.
فکرت, محسن, کی‌پور, فریده   +1 more
core  

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Ruptura esplénica posterior a colonoscopia: complicación infrecuente pero potencialmente letal [PDF]

, 2013
La Colonoscopia es el método diagnostico y terapéutico mas importante en la detección de lesiones tumorales del colon. Sin embargo la perforación y la hemorragia son las complicaciones más frecuentes aunque en un porcentaje bajo en los exámenes ...
Carrera S., Javier, Ibáñez, Heinz, Martínez, Carlos, Mateus, Lina, Rodríguez Fajardo, Jorge E   +4 more
core  

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Spontaneous Splenic Rupture Following Cesarean Section in a Preeclamptic Woman with Twin Pregnancy

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2013
BACKGROUND AND OBJECTIVE: Spontaneous splenic rupture is rare in pregnancy and puerperium, and if the diagnosis and treatment are delayed, maternal mortality and morbidity rates remain extremely high.
M Yaghmaei, M Zamiri Oskouei, S Sadeghi, M Mokhtari   +3 more
doaj  

A case report of successful splenic artery embolization for atraumatic splenic rupture secondary to Epstein Barr virus infection in a haemodynamically unstable patient

Radiology Case Reports
Splenic rupture in haemodynamically unstable patients has traditionally been managed with splenectomy. This case report discusses the successful management of atraumatic splenic rupture, a rare but life-threatening complication of Epstein-Barr virus (EBV)
Naradha Lokuhetty, MBBS (Hons), Moira Tereapii Philip, BBMed MD, Jessica Anne Paynter, MBBS (Hons), BMedSc, Andrew Robert Owen, BSc MBBS MRCP FRCR FRANZCR   +3 more
doaj   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source