Results 111 to 120 of about 27,136 (310)

Self‐Accelerating Bimetallic Peroxide Nanozymes for Cascade‐Amplified Pyroptosis‐Immunotherapy

Advanced Science, EarlyView.
Acidic tumor microenvironment‐responsive CuZnONPs enable triple‐combination therapy via self‐supplying H2O2, cascade nanozyme activities for ROS burst, and Zn2+‐activated pyroptosis, synergizing catalytic therapy with immunotherapy to convert cold tumors into hot ones.
Xuanyi Lu, Liang Li, Siyu Pan, Yuehan Jian, Yuhan Chen, Wenjie Yang, Guang Song, Xueyang Fang, Ping'an Ma, Lijun Jiang   +9 more
wiley   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Spontaneous Splenic Rupture Following Cesarean Section in a Preeclamptic Woman with Twin Pregnancy

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2013
BACKGROUND AND OBJECTIVE: Spontaneous splenic rupture is rare in pregnancy and puerperium, and if the diagnosis and treatment are delayed, maternal mortality and morbidity rates remain extremely high.
M Yaghmaei, M Zamiri Oskouei, S Sadeghi, M Mokhtari   +3 more
doaj  

A case report of successful splenic artery embolization for atraumatic splenic rupture secondary to Epstein Barr virus infection in a haemodynamically unstable patient

Radiology Case Reports
Splenic rupture in haemodynamically unstable patients has traditionally been managed with splenectomy. This case report discusses the successful management of atraumatic splenic rupture, a rare but life-threatening complication of Epstein-Barr virus (EBV)
Naradha Lokuhetty, MBBS (Hons), Moira Tereapii Philip, BBMed MD, Jessica Anne Paynter, MBBS (Hons), BMedSc, Andrew Robert Owen, BSc MBBS MRCP FRCR FRANZCR   +3 more
doaj   +1 more source

Ruptured splenic hydatid cyst

Heliyon
Hydatid cysts of the spleen are rare. Our report details a case wherein an 8-year-old boy with a ruptured splenic hydatid cyst suffered ongoing abdominal pain and shock. Computed Tomography (CT) imaging showed an irregular cyst at the spleen's lower edge with a "floating membranes" sign.
Qiang Guo, Huajin Liu, Guojie Wang
openaire   +3 more sources

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

Splenic Artery Aneurysm Case Report

Case Reports in Obstetrics and Gynecology, 2019
Splenic artery aneurysm rupture is a rare complication of pregnancy with very high maternal and fetal mortality rate. In this paper, a case of splenic artery aneurysm rupture at 34 weeks of gestation with both maternal and fetal survival is presented.
Pouya Abhari, Sina Abhari, Anwar Jackson, Ahmed S. Z. Moustafa, Leo Mercer, Mohammad Ashraf   +5 more
doaj   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Splenic rupture [PDF]

Clinical Medicine, 2019
openaire   +2 more sources