Results 181 to 190 of about 68,138 (263)

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, Volume 13, Issue 45, 13 August 2026.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

CT Features of Granulomatous-Lymphocytic Interstitial Lung Disease (GLILD): The "Kebab Sign" as a Marker to Support Differential Diagnosis. [PDF]

Diagnostics (Basel)
Ciccarese F, Piva N, Carpano M, Bassi I, Guerrieri A, Schifino G, Nava S, Mosconi C, Zompatori M.   +8 more
europepmc   +1 more source

Donor Screening and Stoichiometry Engineering‐Driven Supramolecular Charge‐Transfer Complexes for Synergistic Tumor Near‐Infrared‐II Phototherapy

Aggregate, Volume 7, Issue 8, August 2026.
This work presents 2A‐D2, a supramolecular charge‐transfer complex via donor screening and stoichiometry modulation for near‐infrared‐II phototherapy. Optimizing the assembly ratio induces loose molecular packing, mitigating reactive oxygen species quenching while maintaining high photothermal effects. This synergistic photothermal therapy/photodynamic
Laiping Fang, Yike Tu, Shufang Li, Haiming Feng, Yu Cao, Wenqing Xiao, Jin Fang, Ping'an Ma, Wujun Geng, Guihua Jiang   +9 more
wiley   +1 more source

Systems biology approach unveils the cellular and molecular mechanisms of formalin-inactivated whole cell vaccine-induced protective immunity against <i>Coxiella burnetii</i> infection in mice. [PDF]

Front Immunol
Kumaresan V, Wang D, Zhang Y, Xu D, Zhang G.   +4 more
europepmc   +1 more source

Behind the splenomegaly: a parasitic twist in siblings with beta thalassemia trait. [PDF]

BMC Pediatr
Ali A, Elgharabawi O, Hanson JL, Madigan T, Ferdjallah A.   +4 more
europepmc   +1 more source

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1850-1855, August 2026.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

Spectrum of Primary Immune Regulatory Disorders in Children in a Highly Consanguineous Population: Report from a National Registry. [PDF]

J Clin Immunol
Alajmi A, Alsharidah S, Khalifa N, Elhussein A, Al-Khabaz A, Alaqeel A, Al-Herz W.   +6 more
europepmc   +1 more source

Comparison of Thrombocytopenia and Splenomegaly in Locally Advanced Rectal Cancer Patients Receiving Total Neoadjuvant Therapy With and Without Immunotherapy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background Thrombocytopenia is a common toxicity of oxaliplatin‐based chemotherapy and may be linked to hepatic sinusoidal obstruction and splenic enlargement. In the TORCH trial, adding PD‐1 blockade to an oxaliplatin‐containing total neoadjuvant therapy (TNT) regimen improved tumor response in patients with locally advanced rectal cancer ...
Shuwen Li, Mingxu Yan, Qiong Ma, Yiqun Sun, Zhen Zhang, Lijun Shen, Juefeng Wan, Hui Zhang, Ruiyan Wu, Fan Xia, Yaqi Wang   +10 more
wiley   +1 more source

The Unusual Coexistence of Chronic Lymphocytic Leukemia, Dengue Fever, and Acute Kidney Injury: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT A 70‐year‐old male with CLL presented with dengue fever complicated by AKI. A diagnostic challenge arose from overlapping features. Investigations showed leukocytosis, lymphocytosis, anemia, thrombocytopenia, positive Anti‐Dengue IgM, and renal impairment. Managed with supportive care, ibrutinib, and monitoring, with improvement.
Musawer Khan, Safia Bibi, Zarafshan Khan, F. N. U. Ruqayya, Arwaa Chaudhry, Nauman Khan, Alamzaib Khan, Kamil Ahmad Kamil, F. N. U. Zainullah   +8 more
wiley   +1 more source

Splenic Marginal Zone Lymphoma as a Vascular-Appearing Mass in a Patient With Sustained Virologic Response to Hepatitis C Therapy. [PDF]

Am J Case Rep
Tan XHI, Yee HN, Kwan KWC, Tan AYH, Kok S, Tan MO.   +5 more
europepmc   +1 more source