Results 291 to 300 of about 99,296 (339)

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, Volume 19, Issue 5, Page 1532-1545, May 2025.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

Isolated splenic tuberculosis in an immunocompetent child: A case report. [PDF]

Int J Surg Case Rep
Andaloussi S, Annattah S, Eljiar M, Dalero O, Hassani ZA, Elmadi A.   +5 more
europepmc   +1 more source

Gut Expansion of a Human Lupus Pathobiont is Associated With Autoantibody Production and T Cell Dysregulation

ACR Open Rheumatology, Volume 7, Issue 5, May 2025.
Objective The mechanisms by which the gut microbiome contributes to lupus pathogenesis remain poorly understood. The anaerobe Ruminococcus gnavus (RG) expands in patients with lupus in association with flares. The goal of this study was to determine the mechanisms by which candidate pathobiont lipoglycan‐producing RG2 may contribute to autoimmunity and
Longhuan Ma, Yong Ge, Natalie Six, Seung‐Chul Choi, Josephine Brown, Abigail Castellanos Garcia, Mansour Mohamadzadeh, Gregg J. Silverman, Laurence Morel   +8 more
wiley   +1 more source

Impact of hepatospleno volume ratio on postoperative chronic liver failure after major hepatectomy for perihilar cholangiocarcinoma

Annals of Gastroenterological Surgery, Volume 9, Issue 3, Page 578-586, May 2025.
The hepatospleno volume ratio and prealbumin levels 3 mo after major hepatectomy for perihilar cholangiocarcinoma are significant predictors of postoperative chronic liver failure (PCLF). The importance of this finding is that it emphasizes the need for targeted postoperative nutritional support and regular screening endoscopy to mitigate the risk of ...
Atsushi Takahashi, Yoshihiro Ono, Kosuke Kobayashi, Atsushi Oba, Takafumi Sato, Hiromichi Ito, Yosuke Inoue, Akio Saiura, Yu Takahashi   +8 more
wiley   +1 more source

Integration of anti-PD-1 antibody into chemotherapeutic regimens improved the outcome of aggressive NK cell leukemia: a single-center retrospective real-world analysis. [PDF]

Front Immunol
Shen K, Liao Y, Dai Y, Ji J, Kuang P, Liu Z, Xie L, Niu T, Jiang N, Ma H.   +9 more
europepmc   +1 more source

Structure and Dynamics of the ABL1 Tyrosine Kinase and Its Important Role in Chronic Myeloid Leukemia

Archiv der Pharmazie, Volume 358, Issue 5, May 2025.
Tyrosine kinase inhibitors (TKIs) targeting the ABL1 tyrosine kinase are playing a critical role in the treatment of chronic myeloid leukemia (CML) through the inhibition of persistently activated signaling pathways mediated by the BCR‐ABL1 fusion protein.
Ayca Irgit, Reyhan Kamıs, Belgin Sever, Amaç Fatih Tuyun, Masami Otsuka, Mikako Fujita, Hasan Demirci, Halilibrahim Ciftci   +7 more
wiley   +1 more source

Splenic Irradiation Preceding Allogeneic Hematopoietic Stem Cell Transplantation as a Possible Risk Factor of Sinusoidal Obstruction Syndrome: A Report of Three Cases. [PDF]

Case Rep Oncol
Shirane S, Yasuda H, Uchimura A, Mori Y, Inano T, Tsutsui M, Hamano Y, Ando M.   +7 more
europepmc   +1 more source

Splenomegaly

, 2017
openaire   +1 more source

The Induction and Characterization of a Potential Rough‐Type Brucella Vaccine Candidate Strain RA343, and Its Safety, Protective Efficacy in Mouse and Guinea Pig Models

Animal Research and One Health, Volume 3, Issue 2, Page 195-205, May 2025.
Brucellosis is a zoonotic disease caused by Brucella spp. which seriously jeopardize the health and safety of animals and human beings. In this study, a genetically stable Brucella rough RA343 strain was obtained by cross‐induction. The virulence and protective efficacy of RA343 were subsequently assessed. Overall, the RA343 strain is a promising novel
Linjiao Li, Guangzhi Zhang, Minghe Liu, Lang Lv, Xiaowei Peng, Yu Feng, Xiaotong Yang, Jiabo Ding, Chunhai Liu, Jianhua Qin, Peng Li, Hui Jiang, Xuezheng Fan   +12 more
wiley   +1 more source

Splenic infarction in a paediatric patient with Plasmodium vivax malaria from Ethiopia: a case report. [PDF]

Malar J
Tekle AB, Bekele TT, Solbamo AB, Kebede MA, Berhanu MT, Baramo DD.   +5 more
europepmc   +1 more source