Results 41 to 50 of about 69,111 (289)

Clinical Analysis of Oxaliplatin-related Thrombocytopenia in Patients with Digestive System Malignancy

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the changing trend and correlation of platelet count and spleen diameter in patients with digestive system malignancy receiving oxaliplatin-based chemotherapy. Methods We retrospectively analyzed clinical data of 72 patients with
DAI Yuhong, TAN Ximin, LI Yiming, HUANG Tingting, QIU Hong, QIU Ping   +5 more
doaj   +1 more source

Effectiveness and Safety of Baricitinib for Juvenile Idiopathic Arthritis–Associated Uveitis or Chronic Anterior Antinuclear Antibody–Positive Uveitis

Arthritis Care &Research, EarlyView.
Objective To evaluate the efficacy and safety of baricitinib in pediatric patients with active juvenile idiopathic arthritis–associated uveitis (JIA‐U) or chronic anterior antinuclear antibody–positive uveitis, who had an inadequate response to methotrexate (MTX) or biologic disease‐modifying antirheumatic drugs (bDMARDs).
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Y. Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Investigation and Analysis of Iron-Deficiency Anemia Complicated by Splenomegaly

International Journal of General Medicine, 2021
Yan-hui Wei,1 Yu-zhuo He,2 Xiao-yan Guo,1 Xiao-yan Lin,2 Hong-bin Zhu,2 Xue-jun Guo2 1Department of Graduate School, Xinxiang Medical University, Xinxiang, Henan Province, 453003, People’s Republic of China; 2Department of Hematology, Puyang Oilfield ...
Wei Y, He Y, Guo X, Lin X, Zhu H, Guo X
doaj  

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Sarcoidosis presenting as isolated massive splenomegaly: A case report

Clinical Case Reports
Key Clinical Message Sarcoidosis is a systemic granulomatous disease with an unknown cause, marked by the presence of noncaseating granulomas in the affected organs.
Melissa Kyriakos Saad, Imad El Hajj, Elias Saikaly   +2 more
doaj   +1 more source

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer

Advanced Science, EarlyView.
This carrier‐free, esterase‐responsive nanoaggregate integrates a mitochondria‐targeting photosensitizer with a non‐nucleotide STING agonist to achieve localized photoactivation and immune reprogramming. ICyM2 remodels tumor stroma, induces potent immunogenic cell death, and triggers intratumoral STING activation, collectively revitalizing the ...
Yixuan Zhang, Shankun Yao, Yihan Zhao, Saisai Zhu, Wen Fang, Ranran Yu, Naiwen Shi, Ruixin Zhang, Yin Zhang, Jiawei Liang, Ziying Zhang, Shijin Xu, Ziwei Zhang, Jiajun Zhang, Yukun Li, Xiaoxuan Han, Yuncong Chen, Shu Zhang, Ying Lv   +18 more
wiley   +1 more source

A misleading miscellanea: a COVID-19 patient with fever and cytopenia

Italian Journal of Medicine
Complex clinical cases characterized by the coexistence of multiple pathologies and, consequently, multiple signs and symptoms shared by various pathological entities can hide pitfalls that may lead to incorrect diagnostic conclusions due to cognitive ...
Pietro Bocchi, Lara Zerbini, Elisa Gnappi, Maurizio Ziliotti, Marco Pesci, Luisa Craviotto, Michele Meschi   +6 more
doaj   +1 more source

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source

Gaucher’s Disease – What Should You Know

Quality in Sport
Gaucher’s Disease (GD) has a special place among ultra-rare diseases, which is a disease that occurs in less than onein 50 000 persons. The disease is caused by a hereditary autosomal deficiency of the lysosomal enzyme glucocerebrosidase.
Dominika Podgórska, Karolina Jurasz, Miłosz Sanecki, Karolina Tomczyk, Natalia Chojnacka, Ewa Rzeska, Jakub Klarycki, Radosław Cymer   +7 more
doaj   +1 more source