Results 71 to 80 of about 138,072 (341)

Model for End‐Stage Liver Disease/Pediatric End‐Stage Liver Disease exception policy and outcomes in pediatric patients with hepatopulmonary syndrome requiring liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Hepatopulmonary syndrome (HPS) is associated with increased waitlist mortality in liver transplantation (LT) candidates. Children with HPS are granted Model for End‐Stage Liver Disease (MELD)/Pediatric End‐Stage Liver Disease (PELD) exception points for waitlist prioritization in the United States based on criterion developed for adults.
Muhammad H. Raza, Yong Kwon, Pierre Kobierski, Asish C. Misra, Angelina Lim, Cameron Goldbeck, Kambiz Etesami, Rohit Kohli, Juliet Emamaullee   +8 more
wiley   +1 more source

A multi-parametric analysis of Trypanosoma cruzi infection: common pathophysiologic patterns beyond extreme heterogeneity of host responses [PDF]

, 2017
The extreme genetic diversity of the protozoan Trypanosoma cruzi has been proposed to be associated with the clinical outcomes of the disease it provokes: Chagas disease (CD).
Chillón-Marinas, Carlos, Fernandez-Cortes, Fernando, Fresno, Manuel, Gironès, Núria, González-Rubio, María-Luisa, Martin, David, Santi-Rocca, Julien   +6 more
core   +3 more sources

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

A misleading miscellanea: a COVID-19 patient with fever and cytopenia

Italian Journal of Medicine
Complex clinical cases characterized by the coexistence of multiple pathologies and, consequently, multiple signs and symptoms shared by various pathological entities can hide pitfalls that may lead to incorrect diagnostic conclusions due to cognitive ...
Pietro Bocchi, Lara Zerbini, Elisa Gnappi, Maurizio Ziliotti, Marco Pesci, Luisa Craviotto, Michele Meschi   +6 more
doaj   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Gaucher’s Disease – What Should You Know

Quality in Sport
Gaucher’s Disease (GD) has a special place among ultra-rare diseases, which is a disease that occurs in less than onein 50 000 persons. The disease is caused by a hereditary autosomal deficiency of the lysosomal enzyme glucocerebrosidase.
Dominika Podgórska, Karolina Jurasz, Miłosz Sanecki, Karolina Tomczyk, Natalia Chojnacka, Ewa Rzeska, Jakub Klarycki, Radosław Cymer   +7 more
doaj   +1 more source

Surgical treatment of spontaneous spleen rupture in patients with splenomegalia [PDF]

Scripta Medica, 2018
Spontaneous spleen rupture rarely occurs, and is primarily present in patients with splenomegaly. This is a life-threatening condition that, without adequate surgical treatment, always ends lethally.
Đeri Jugoslav, Simatović Milan, Vujanović Vojo, Topić Duško   +3 more
doaj  

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Granulomatous Lymphocytic Interstitial Lung Disease (GLILD) in Common Variable Immunodeficiency (CVID): A Multicenter Retrospective Study of Patients From Italian PID Referral Centers

Frontiers in Immunology, 2021
Background: Granulomatous and Lymphocytic Interstitial Lung Diseases (GLILD) is a severe non-infectious complication of Common Variable Immunodeficiency (CVID), often associated with extrapulmonary involvement.
Francesco Cinetto, Francesco Cinetto, Riccardo Scarpa, Riccardo Scarpa, Maria Carrabba, Davide Firinu, Vassilios Lougaris, Vassilios Lougaris, Helena Buso, Helena Buso, Giulia Garzi, Sabrina Gianese, Sabrina Gianese, Valentina Soccodato, Alessandra Punziano, Gianluca Lagnese, Giulio Tessarin, Giulio Tessarin, Giulia Costanzo, Nicholas Landini, Stefania Vio, Maria Pia Bondioni, Dario Consonni, Carolina Marasco, Stefano Del Giacco, Marcello Rattazzi, Marcello Rattazzi, Angelo Vacca, Alessandro Plebani, Alessandro Plebani, Giovanna Fabio, Giuseppe Spadaro, Carlo Agostini, Carlo Agostini, Isabella Quinti, Cinzia Milito   +35 more
doaj   +1 more source

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Advanced Science, EarlyView.
This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu, Xingyu Zhang, Jingjia Zhang, Gaohui Huang, Chen Zhou, Chunlin Li, Xiaojun Huang, Jianbo Xiao, Nianjie Feng, Yuanbin She   +9 more
wiley   +1 more source