Results 71 to 80 of about 11,116 (261)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance

Advanced Science, EarlyView.
Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng, Masaki Nasu, Ayman Abdul‐Ghani, Yu Chen, Shaoqiu Chen, Isam Mohd Ibrahim, Hanqiu Zhang, Lauren Higa, Zitong Gao, Hua Yang, Raphael Bueno, Loïc Le Marchand, Youping Deng   +12 more
wiley   +1 more source

Hermite bicubic spline collocation method for Poisson's equations

Journal of Numerical Analysis and Approximation Theory, 2004
In this paper is presented a bicubic spline collocation method for the numerical approximation of the solution of Dirichlet problem for the Poisson's equation.
Mihaela Puşcaş
doaj   +2 more sources

Approximation of Double-dimensional Densities of Probabilities by Orthogonal Bases

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2009
Approach to approximation of double-dimensional densities of probabilities in rectangle areas by the families of double-dimensional orthogonal functions created by multiplication of single-dimensional orthogonal functions is studied. Calculation formulas
l. A. Lyozin
doaj   +1 more source

EndoTac: An Endoscopic Camera‐Based Tactile Sensor with High Sensitivity for Minimally Invasive Surgery

Advanced Science, EarlyView.
EndoTac presents a trocar‐compatible endoscopic vision‐based tactile sensor that uses a convex mirror to enlarge side‐facing tactile coverage during minimally invasive vessel palpation. Distorted tactile images are unwarped and processed by a learning model to estimate vascular deformation, enabling sensitive, spatially distributed tactile perception ...
Yupeng Wang, Nicolas Raison, Xuyang Zhang, Aijia Yang, Lukas Lindenroth, Shan Luo   +5 more
wiley   +1 more source

Dynamic Programming as a Method of Spline Approximation in the CAD Systems of Linear Constructions

Российский технологический журнал, 2019
Under study is a problem of the line structure routing of roads, railways and other linear constructions. Designing a trace plan and longitudinal profile are considered as non-linear programming tasks.
D. A. Karpov, V. I. Struchenkov
doaj   +1 more source

Hierarchical Spline Approximation

, 2001
We discuss spline refinement methods that approximate multi-valued data defined over one, two, and three dimensions. The input to our method is a coarse decomposition of the compact domain of the function to be approximated consisting of intervals (univariate case), triangles (bivariate case), and tetrahedra (trivariate case).
Wiley, David F., Bertram, Martin, Hamann, Bernd, Joy, Ken, Max, Nelson, Scheuermann, Gerik   +5 more
openaire   +2 more sources

Copositive Polynomial and Spline Approximation

Journal of Approximation Theory, 1995
Here the authors prove that if a function \(f \in \mathbb{C} [0.1]\) changes sign finitely many times then for any \(n\) large enough the degree of copositive approximation to \(f\) by quadratic splines with \(n-1\) equally spaced knots can be estimated by a constant multiple of \(\omega_2 (f,1/n)\).
Hu, Y.K., Leviatan, D., Yu, X.M.
openaire   +1 more source

Performance Estimation and Ex Vivo Validation of Untethered Magnetic Robots in Soft Tissue

Advanced Science, EarlyView.
This study presents an empirical model that quantitatively predicts the step‐out frequency of screw‐type untethered magnetic robots (UMRs) in soft viscoelastic environments, including ex vivo brain tissue. By integrating key parameters into a dimensionless framework, the model enables estimation of robot performance across a range of biological ...
Leendert‐Jan W. Ligtenberg, Thijs J. van der Burg, Stijn Y. Kolkman, Santiago Saavedra Castano, David Fernandez Rivas, Anke Klingner, Roger M. L. M. Lomme, Lucas S. Joziasse, Dorothee Wasserberg, H. Remco Liefers, Doron Ben Ami, Udi Sadeh, Oded Shoseyov, Giulio Dagnino, Pascal Jonkheijm, Jurgen J. Fütterer, Stefano Stramigioli, J. Frank W. Nijsen, Michiel C. Warlé, Islam S. M. Khalil   +19 more
wiley   +1 more source

USING SPLINE FUNCTIONS FOR THE SUBSTANTIATION OF TAX POLICIES BY LOCAL AUTHORITIES [PDF]

Annals of the University of Oradea: Economic Science, 2011
The paper aims to approach innovative financial instruments for the management of public resources. In the category of these innovative tools have been included polynomial spline functions used for budgetary sizing in the substantiating of fiscal and ...
Otgon Cristian, Pop Razvan, Bolos Marcel
doaj