Results 201 to 210 of about 51,949 (268)

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Flexible statistical approaches for modeling nonlinear relationships in diabetes prediction using splines, Bayesian kernel regression and Bayesian regression trees. [PDF]

Discov Anal
Ranathungage TD, Blumer H, Muthukumarana S.   +2 more
europepmc   +1 more source

Prioritizing Modifiable Risk Factors for Cardiovascular Diseases in Adults With Hypertension: A Prospective Cohort Study

Med Research, EarlyView.
This study examined the relative contributions of modifiable risk factors to cardiovascular diseases in adults with hypertension. More favorable risk factor profiles were consistently associated with lower risks across all outcomes. Beyond blood pressure, nicotine exposure showed comparatively larger population attributable fractions.
Shengtao Wei, Dashan Zheng, Lan Chen, Zitong Zhuang, Zihan Lin, Junguo Zhang, Peng Hu, Zijun Yang, Zhen‐He Huang, Bing Zhang, Hualiang Lin   +10 more
wiley   +1 more source

The toxin–antitoxin complex Fic‐1–AntF functions as a deAMPylase that regulates the activity of DNA gyrase

mLife, EarlyView.
Abstract Toxin–antitoxin (TA) systems found in diverse bacteria play important roles in their adaptation to changing environments. The toxin of the Fic‐1–AntF TA pair from Pseudomonas bijieensis strain 2P24 inhibits bacterial DNA replication by attacking the subunit B of DNA gyrase (GyrB) via AMPylation, while the antitoxin AntF blocks its enzymatic ...
Furong Chen, Liwei Guo, Canhua Lu, Wenjun Jiang, Zhao‐Qing Luo, Junfeng Liu, Li‐Qun Zhang   +6 more
wiley   +1 more source

Pulsed field ablation: Biophysical principles and practical considerations in atrial fibrillation treatment. [PDF]

Indian Pacing Electrophysiol J
Patil S, Kapa S, Deshmukh AJ.
europepmc   +1 more source

Interaction effects of testosterone and platelet-to-lymphocyte ratio on osteoporosis in U.S. adults: Insights from the NHANES 2011 to 2016 cohort. [PDF]

Medicine (Baltimore)
Tao C, Liu Y, Shen H, Li T, He Y.
europepmc   +1 more source

Association of hemoglobin-to-red blood cell distribution width ratio (HRR) and sleep duration with stroke: A cross-sectional study from NHANES 2008-2018. [PDF]

Medicine (Baltimore)
Xue H, Zhao Y, Xu H, Si X, Song K, Jia M.   +5 more
europepmc   +1 more source

Network meta-analysis with dose-response relationships. [PDF]

BMC Med Res Methodol
Petropoulou M, Rücker G, Schwarzer G.
europepmc   +1 more source

Association between mushroom consumption and digit span performance among middle-aged and older community-dwelling Japanese: the NILS-LSA project.

Food Funct
Zhang S, Ba DM, Nishita Y, Tange C, Zhu J, Otsuka R, Muscat J.   +6 more
europepmc   +1 more source

Capturing infant and child growth dynamics with P-splines mixed effects models

Hernandez MA, Li Z, Cole TJ, Ong YY, Tilling K, Elhakeem A.   +5 more
europepmc   +1 more source