Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Relative Efficiency of split plot design [PDF]
, 1982 DHAMU A.P, A SHANMUGASUBRAMANIAN
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Analytical Study in Split-Plot Design with Application on an Agricultural Laboratory Experiment
, 2022 Shrook AL-Sabbah +2 more
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
A field experiment was conducted at the farm of Faculty of Agriculture, Moshtohor, Benha University during the 1998/1999 and 1999/2000 winter seasons. The study aimed to evaluate the productive characteristics of two squash cultivars (Eskandarani and Arlika F1 hybrid) that fertilized through 100% biogas fertilizer, 50% biogas + 50% mineral fertilizer and 100% mineral fertilizer on nitrogen basis (60 kg N/ feddan) with or without seed vernalization. Treatments were arranged in split plot design w [PDF]
, 2007 Nadia Shafshak, A. Aggour, Seham Ali
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Journal of the Saudi Society of Agricultural SciencesTo evaluate the performance of wheat genotypes under different nitrogen doses, a field trial was conducted at the Nepal Agricultural Research Council (NARC), Khumaltar, Lalitpur. Two genotypes (NL1330 and WK1204) were combined with six nitrogen doses (50,
Samir Neupane +8 more
doaj +1 more source
Study protocol for a cluster-randomized split-plot design trial to assess the effectiveness of targeted active malaria case detection among high-risk populations in Southern Lao PDR (the AcME-Lao study). [PDF]
Gates Open Res, 2019 Lover AA +13 more
europepmc +1 more source