Results 211 to 220 of about 1,281,558 (307)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

BA-Pred and RMSD-Pred: Integrated Graph Neural Network Models for Accurate Protein-Ligand Binding Affinity and Binding Pose Prediction. [PDF]

J Chem Inf Model
Sim J, Lee J.
europepmc   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Split decision [PDF]

Nature, 2012
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Classification of Cochrane Plain Language Summaries by Conclusiveness Using Transformer-Based Models and ChatGPT: Retrospective Observational Study.

JMIR Med Inform
Mijatović A, Ursić L, Bralić N, Bandić R, Ćaćić B, Buljan I, Marušić A.   +6 more
europepmc   +1 more source

Defining the Society of Pediatric Liver Transplantation (SPLIT) research agenda: A Delphi consensus project. [PDF]

Hepatol Commun
Wadhwani SI, Spector PR, Feldman AG, Furuya KN, Hartjes K, Jarasvaraparn C, Kelly B, Lerret SM, Mysore K, Pawaria A, Rosenthal P, Shui A, Slowik V, Taylor S, Vittorio J, Valentino PL, Society of Pediatric Liver Transplantation (SPLIT).   +16 more
europepmc   +1 more source

Split Personality

Mens Sana Monographs, 2016
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Rare Case of Combined Tibial Plateau Fracture with Tibial Tuberosity Avulsion Injury: Case Report. [PDF]

J Orthop Case Rep
Salikity SA, Sreenivas KD, Iytha MS, Abraham VT, Sharma A, Rajashekar JV.   +5 more
europepmc   +1 more source