Results 101 to 110 of about 652,005 (320)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Журнал Белорусского государственного университета: Математика, информатика, 2018 Let Lm(k) denote the class of edge intersection graphs of k-chromatic hypergraphs with multiplicity at most m. It is known that the problem of recognizing graphs from L1(k) is polynomially solvable if k = 2 and is NP-complete if k = 3.
Tatiana V. Lubasheva, Yury M. Metelsky
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Using fuzzy clustering to reconstruct alert correlation graph of intrusion detection
Tongxin xuebao, 2006 Causal correlation method was one of the most representative methods for instruction detection alert correla-tion. In some conditions, the correlation graph would be split because of loss of causal information. In order to solve the problem, an algorithm
MA Lin-ru1 +3 more
doaj +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Forbidden subgraphs of TI-power graphs of finite groups
Open MathematicsGiven a finite group GG with identity ee, the TI-power graph (trivial intersection power graph) defined on GG, denoted by Γ(G)\Gamma \left(G), is an undirected graph with vertex set GG where distinct vertices aa and bb are adjacent if ⟨a⟩∩⟨b⟩={e}\langle ...
Li Huani, Chen Jin, Lin Shixun
doaj +1 more source
Semi-strong split domination in graphs [PDF]
Transactions on Combinatorics, 2014 Given a graph $G = (V,E)$, a dominating set $D subseteq V$ is called a semi-strong split dominating set of $G$ if $|V setminus D| geq 1$ and the maximum degree of the subgraph induced by $V setminus D$ is 1.
Anwar Alwardi +3 more
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