Results 251 to 260 of about 2,136,365 (369)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Characterization of Models for Identifying Physical and Cognitive Frailty in Older Adults With Diabetes: Systematic Review and Meta-Analysis.

J Med Internet Res
Wang X, Meng S, Xiao X, Lu L, Chen H, Li Y, Zhang R, Jiang Q, Liu S, Gao R.   +9 more
europepmc   +1 more source

Diagnostic performance of machine learning and deep learning algorithms for thyroid cancer metastasis: a systematic review and meta-analysis. [PDF]

BMC Med Inform Decis Mak
Lichahi MA, Anvari S, Hemmati H, Zadgari E, Jafari M, Mirkalaie SMM, Farzin M, Larijani A.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Assessing healthy distrust in human-AI interaction: interpreting changes in visual attention. [PDF]

Front Psychol
Peters TM, Biermeier K, Scharlau I.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Clarifying the reliability paradox: poor measurement reliability attenuates group differences. [PDF]

Front Psychol
Karvelis P, Diaconescu AO.
europepmc   +1 more source

Multiple objective Pareto frontier optimization for split-plot experiments

Christine M. Anderson‐Cook, Lu Lu, Timothy J. Robinson   +2 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Exploring the synergy between aluminum powder and silica fume in enhancing lightweight concrete characteristics. [PDF]

Sci Rep
Khan MB, Baarimah AO, Banaimoon MSM, Ramu MB, Ebrahim AFMS, Alsulami BT, Almujibah H.   +6 more
europepmc   +1 more source