Results 271 to 280 of about 2,136,365 (369)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Age-dependent immune responses and resident cell dynamics in young mice following pneumonia. [PDF]

open access: yesiScience
Michki SN   +7 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

Wilkinson dot plots and intervals showing the distribution of the probability assigned to points in the 2024 testing data by the ensemble model, split by class (whether the point was a true tick presence point or a background point).

open access: green
Mark Gideon Burdon (22404063)   +7 more
openalex   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

Evaluation of phosphorus fertilizer sources and nitrogen optimization for wheat and tef in Ethiopia's central highlands. [PDF]

open access: yesSci Rep
Gete Y   +10 more
europepmc   +1 more source

CONSTRUCTION OF SPLIT PLOT DESIGN FOR ESTIMATING VARIANCE COMPONENT

open access: green, 2014
Oluwole Adegoke Nuga   +2 more
openalex   +1 more source

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