Results 161 to 170 of about 392,166 (257)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Patients with autism spectrum disorders at the Department of Pediatrics, University hospital of Split

Ciljevi: Cilj ovog istraživanja bio je istražiti udio značajnih perinatalnih događaja, pojedinih kliničkih slika, komorbiditeta i terapijskih opcija u djece s poremećajima iz spektra autizma u Klinici za dječje bolesti KBC-a Split.
Kovačić, Julian
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Kawasaki syndrome; clinical symptoms and treatment of patients in the Clinical Hospital Centre Split; in the period from 1995 to 2013

, 2014
Ciljevi: Cilj ovog istraživanja bio je prikupiti podatke o kliničkoj slici, liječenju i ishodu bolesnika liječenih pod dijagnozom Kawasakijeva sindroma u KBC Split u razdoblju od 1995. - 2013. i usporediti ih sa podatcim iz literature.
Plazibat, Marija
core  

Does split-suckling influence pre- and postweaning pig growth performance and mortality? [PDF]

Transl Anim Sci
Spinler MS, Woodworth JC, Tokach MD, Goodband RD, DeRouchey JM, Gaffield KN, Hartman AR, Cross A, McNeil B, Gebhardt JT.   +9 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A novel approach for the EEG-driven assessment of divided attention through mutual information theory: A case study at the wheel. [PDF]

PLoS One
Ronca V, Capotorto R, Giorgi A, Dello Iacono F, Cecchetti M, Napoletano L, Brambati F, Borghini G, Aricò P, Di Flumeri G.   +9 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Comparative Analysis of High-Torque-Density Permanent Magnet Motors Having Similar Slot and Pole Numbers for Humanoid Robot Applications. [PDF]

Biomimetics (Basel)
Bi K, Chen Z, He T.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source