Results 151 to 160 of about 659,828 (336)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Influence of the Front Shape of Splitter Vanes on the Performance of the Vane Type Multiphase Pump
Shiyou jixieThe vane type multiphase pump is prone to produce vane tip leakage vortex and gas-liquid separation under gas-liquid conditions,which directly leads to reduced pump performance,thereby affecting the pump delivery efficiency and increasing the production ...
Sun Dianxin
doaj
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Lip noise generated by flow separation from nozzle surfaces [PDF]
The results of a series of experiments, performed to investigate flow separation and classic lip noise and to aid in understanding aeroacoustic noise generation are presented.
Karchmer, A., Olsen, W.
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Journal of Applied Fluid Mechanics, 2017 Impellers with splitter blades are used for pumps and compressors in the design of turbomachines. Design parameters such as the number of blades, blade discharge angle and impeller discharge diameter impact affect pump performance and energy consumption.
E. Korkmaz, M. Gölcü, C. Kurbanoğlu
doaj
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Two-dimensional transonic testing with splitter plates [PDF]
The use of splitter plates for two dimensional transonic testing in wind tunnels was investigated on a 12% biconvex airfoil section over the Mach number range 0.6 to 1.0.
Davis, S., Satyanarayana, B.
core +1 more source