Results 21 to 30 of about 149 (149)

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Splitting algorithms and circuit analysis

, 2022
The splitting algorithms of monotone operator theory find zeros of sums of relations. This corresponds to solving series or parallel one-port electrical circuits, or the negative feedback interconnection of two subsystems. One-port circuits with series and parallel interconnections, or block diagrams with multiple forward and return paths, give rise to
Chaffey, Thomas, Das, Amritam, Sepulchre, Rodolphe   +2 more
openaire   +2 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

An FPT Algorithm for Bipartite Vertex Splitting

, 2023
Appears in the Proceedings of the 30th International Symposium on Graph Drawing and Network Visualization (GD 2022)
Reyan Ahmed, Stephen Kobourov, Myroslav Kryven   +2 more
openaire   +2 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Splitting the Conditional Gradient Algorithm

SIAM Journal on Optimization
We propose a novel generalization of the conditional gradient (CG / Frank-Wolfe) algorithm for minimizing a smooth function $f$ under an intersection of compact convex sets, using a first-order oracle for $\nabla f$ and linear minimization oracles (LMOs) for the individual sets.
Zev Woodstock, Sebastian Pokutta
openaire   +2 more sources

Monte Carlo modeling of radiation dose from radiation therapy with superficial x‐rays

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction Superficial x‐rays (50–100 kVp) are used for treating non‐melanoma skin cancer and intraoperative radiation therapy (IORT). At these energies, the photoelectric effect significantly increases absorbed dose to bone compared to soft tissue.
Reham Barghash, Tiffany W. Martin, Amber R. Prebble, Del Leary   +3 more
wiley   +1 more source

‘Split radix’ FFT algorithm

Electronics Letters, 1984
A new N = 2n fast Fourier transform algorithm is presented, which has fewer multiplications and additions than radix 2n, n = 1, 2, 3 algorithms, has the same number of multiplications as the Raderi-Brenner algorithm, but much fewer additions, and is numerically better conditioned, and is performed ‘in place’ by a repetitive use of a ‘butterfly’-type ...
Henk D. L. Hollmann, Pierre Duhamel
openaire   +2 more sources

A Traffic Splitting Algorithm for Load Balancing in Tor

Entropy, 2022
As the most popular anonymous communication system, Tor provides anonymous protection for users by sending their messages through a series of relays. Due to the use of the bandwidth-weighted path selection algorithm, many more users choose routers with high bandwidth as relays. This will cause the utilization of high bandwidth routers to be much higher
Xiance Meng, Mangui Liang
openaire   +3 more sources