Results 111 to 120 of about 56,684 (289)

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Connecting inflammation, blood vessels and bone in spondyloarthritis [PDF]

, 2022
Spondyloarthritis is one of the most frequent forms of chronic inflammatory arthritis, which affects both axial and peripheral joints. Spondyloarthritis is characterized by inflammation, new bone formation and bone destruction.
Kaaij, M.H.
core   +2 more sources

Demographic, clinical, laboratory and treatment characteristics of spondyloarthritis patients with and without acute anterior uveitis

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Acute anterior uveitis is a common extra-articular manifestation in spondyloarthritis patients. The aim of this study was to compare demographic, clinical, laboratory and treatment data among spondyloarthritis patients with and ...
Marcelo Gehlen, Kelly Cristina Regis, Thelma Larocca Skare   +2 more
doaj   +1 more source

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis

Nature Communications, 2017
Spondyloarthritis is an inflammatory disease with Th17 cells implicated in the pathogenesis. Here the authors show that patients with spondyloarthritis have increased numbers of GM-CSF-secreting blood and synovial lymphocytes, Th17 or not, that carry a ...
M. H. Al-Mossawi, L. Chen, H. Fang, A. Ridley, J. de Wit, N. Yager, A. Hammitzsch, I. Pulyakhina, B. P. Fairfax, D. Simone, Yao Yi, S. Bandyopadhyay, K. Doig, R Gundle, B. Kendrick, F. Powrie, J. C. Knight, P. Bowness   +17 more
doaj   +1 more source

Improvement of Signs and Symptoms of Nonradiographic Axial Spondyloarthritis in Patients Treated With Secukinumab: Primary Results of a Randomized, Placebo‐Controlled Phase III Study

Arthritis & Rheumatology, 2020
To report the primary (1‐year) results from PREVENT, the first phase III study evaluating secukinumab in patients with active nonradiographic axial spondyloarthritis (SpA).
A. Deodhar, R. Blanco, E. Dokoupilova, S. Hall, H. Kameda, A. Kivitz, D. Poddubnyy, M. van de Sande, A. Wiksten, B. Porter, H. Richards, Sibylle Haemmerle, J. Braun   +12 more
semanticscholar   +1 more source

Successful treatment of eosinophilic esophagitis with upadacitinib prescribed for atopic dermatitis

JPGN Reports, EarlyView.
Abstract We describe a pediatric patient treated with upadacitinib for atopic dermatitis (AD) who subsequently achieved sustained clinical and histologic remission of eosinophilic esophagitis (EoE). Upadacitinib is an oral small molecule selective Janus kinase 1 inhibitor that inhibits janus kinase‐signal transduction and activation of transcription ...
Nathalie Nguyen, Maureen Bauer
wiley   +1 more source

Development of an ASAS-endorsed recommendation for the early referral of patients with a suspicion of axial spondyloarthritis

, 2015
The aim of this work was to develop a consensual recommendation under the auspices of the Assessment of SpondyloArthritis international Society (ASAS) for early referral of patients with a suspicion of axial spondyloarthritis by non-rheumatologists.
Sieper, J., van der Heijde, D., Heijde, D. van der, Landewé, R., Assessment of SpondyloArthritis, the, Tubergen, A. van, van Tubergen, A., Poddubnyy, D., Assessment SpondyloArthrit Int Soc   +8 more
core   +1 more source

STEM CELL TRANSPLANTATION AS A POSSIBLE STRATEGY FOR TREATING STANDARD THERAPY-RESISTANT ANKYLOSING SPONDYLITIS

Современная ревматология, 2016
The authors have analyzed the literature dealing with studies of the efficiency and safety of stem cell transplantation (SCT) in patients with ankylosing spondylitis (AS) through the electronic resources Pubmed and Medline by using the keywords «bone ...
I. Z. Gaidukova, V. V. Ushakova, A. P. Rebrov   +2 more
doaj   +1 more source

Eighth International Congress on Spondyloarthritis

Современная ревматология, 2013
In 1998 the First Congress of the European Ankylosing Spondylitis (AS) Working Group was held and attended by 9 leading experts from Germany and the Netherlands.
Anna Georgiyevna Bochkova
doaj   +1 more source

Impact of fibromyalgia on patient acceptable symptom state in Thai patients with spondyloarthritis: A cross‐sectional study

Rheumatology &Autoimmunity, EarlyView.
This cross‐sectional study enrolled Thai patients with spondyloarthritis to assess the prevalence and its impact. Fibromyalgia was present in 5.5% and significantly impaired health‐related quality of life and symptom perception. Low disease activity, good sleep quality, and FS < 3 were independently associated with achieving PASS.
Sittikorn Srivorrapattararkul, Praveena Chiowchanwisawakit   +1 more
wiley   +1 more source