Results 211 to 220 of about 343,445 (359)

Tumor Extracellular Vesicles Aggravate Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
This study reveals a novel mechanistic connection between cancer and ischemia/reperfusion (I/R)‐induced cardiac injury. The meta‐analysis demonstrates significantly higher incidence ratios of both all‐cause mortality and cardiovascular mortality in cancer patients undergoing percutaneous coronary intervention (PCI) compared to non‐cancer patients.
Zhongting Mei   +14 more
wiley   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin   +9 more
wiley   +1 more source

Harnessing Bifunctional Nitrogen‐Dislocation Interactions for a Record Ultra‐Strong‐and‐Ductile Duplex Titanium Alloy

open access: yesAdvanced Science, EarlyView.
By engineering bifunctional nitrogen‐dislocation interactions, this work constructs a heterogeneous lamellar structure with N‐rich low‐angle boundaries and coherent nanotwinned martensites, enabling ultrahigh yield/tensile strength (1532/1869 MPa) and activating massive dislocations via stress‐driven bow‐out/cross‐slip.
Chongle Zhang   +5 more
wiley   +1 more source

Olfactory mucosal mesenchymal stem cells delivered by gelatin sponge scaffolds promote functional recovery of spinal cord injury. [PDF]

open access: yesFront Bioeng Biotechnol
Li W   +13 more
europepmc   +1 more source

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

open access: yesAdvanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang   +13 more
wiley   +1 more source

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