Results 71 to 80 of about 19,753 (306)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Therapeutic theatre and spontaneity: Goethe and Moreno

, 2006
Moreno noted a similarity between a late 18th Century play by the great German scholar and artist, Goethe, and some elements of psychodrama, which can be substantiated; however, Goethe was not, as Moreno suggested, an early promoter of spontaneity.
Scheiffele, Eberhard
core  

General Decision-Making Style: Testing the Russian-Language Modification of the GDMS Questionnaire

Вестник Московского университета. Серия 14: Психология
Background. Individual techniques, or decision-making styles, are included in the regulation of hierarchies of processes that mediate a person’s exit from situations of uncertainty.
Tatiana V. Kornilova
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Freedom, Spontaneity, and Our Encounters

Political Philosophy
This article defends the significance of our encounters on the grounds of their distinctive contribution to our freedom. The variety and novelty of our encounters, and the spontaneity they allow us in the shaping of our selves, creates opportunities for ...
Emily McTernan
doaj   +2 more sources

Reflection on

Journal of Trial and Error, 2020
"Trial and Error (-related negativity)" is a fascinating paper detailing the attempt to develop a new experimental paradigm to study the role of error-related negativity in the development of avoidance behavior.
Maarten Derksen
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Do children with autism use the Picture Exchange Communication System (PECS) to make spontaneous requests?

, 2010
This review examines the research on the Picture Exchange Communication System(PECS), which has become a popular communication strategy for children withautism and other communication disorders.
Farrer, Amy
core  

Some special features of spanish spesch strategy and tactics

Polylinguality and Transcultural Practices, 2012
The article is focused on the manner of Spaniard to speak, to conduct dialogue, converting it into the monologue and vice versa. We consider that such features as exaggerated loudness, repetitions of the same words, abuse of superlative degree ...
M V Kutieva
doaj