From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Spontaneous Rupture of Proximal Ureter: A Case Report [PDF]
Spontaneous non-traumatic urinary collecting system ruptures without distal obstructive causes are rare and uncommon. They should be considered in the differential diagnosis of renal colic or acute abdomen.
Fatih Çolak +7 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Reliability of "Google" for obtaining medical information
Internet is used by many patients to obtain relevant medical information. We assessed the impact of "Google" search on the knowledge of the parents whose ward suffered from squint.
Mihir Kothari, Samita Moolani
doaj +1 more source
Spontaneous Symmetry Breaking (II): Variations in Complex Models [PDF]
This paper, part II of a two-part project, continues to explore the meaning of spontaneous symmetry breaking (SSB) by applying and expanding the general notion we obtained in part I to some more complex and, from the physics point of view, more important
Liu, Chuang
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Spontaneous abortion treatment with acupuncture and Cordyceps sinensis [PDF]
Spontaneous abortion or miscarriage is very common nowadays. Our patient is a 38 year old woman with history of four spontaneous abortions and inability to carry the baby after 12th week of pregnancy with positive CMV IgG results.
Kozovska, Kristina +2 more
core +1 more source
Spontaneous Splenic Rupture in an Ill Returned Traveller
Spontaneous splenic rupture is a known, but rare and possibly fatal, complication of different infectious diseases. We present a case of a 38-year-old male patient who presented with fever, icterus and spontaneous splenic rupture after a visit to Vietnam
David FGJ Wolthuis +2 more
doaj +1 more source
The Meaning of Spontaneous Symmetry Breaking (I): From a simple classical model [PDF]
This paper, part I of a two-part project, aims at answering the simple question 'what is spontaneous symmetry breaking?' by analyzing from a philosophical perspective a simple classical model.
Liu, Chuang
core

