Results 191 to 200 of about 88,781 (260)

Real‐world treatment patterns and outcomes among patients with immune thrombocytopenia (ITP) who switched treatment from eltrombopag or romiplostim to avatrombopag in the United States: Results from the REAL‐AVA 3.5 study

British Journal of Haematology, EarlyView.
Summary Real‐world data on treatment response after switching between thrombopoietin receptor agonists are limited for patients with immune thrombocytopenia (ITP). The objective of this study is to describe treatment patterns and outcomes in patients with primary ITP who switched from eltrombopag (ELT) or romiplostim (ROMI) to avatrombopag (AVA).
Caroline Piatek, Abiola Oladapo, Scott Kolodny, Michael Vredenburg, Sarah Lucht, Emily Bland, Prathamesh Pathak, Bruce Feinberg, Hillary Maitland   +8 more
wiley   +1 more source

Spontaneous remission without treatment of acute myelomonocytic leukemia associated with COVID-19 infection. [PDF]

Hematol Transfus Cell Ther
Peñuela R, Hernandez I, Fernandes-Pineda M, Cortina L, Zapata D, Urrego O, Herrera J, Saenz I, Orduz R, Mejia F, Moreno L, Velazco M.   +11 more
europepmc   +1 more source

From a novel pathogenic SAMD9L variant to cohort‐wide insights: Whole‐genome sequencing highlights somatic genetic rescue and phenotypic heterogeneity

British Journal of Haematology, EarlyView.
Summary Germline gain‐of‐function variants in sterile alpha motif domain–containing 9‐like (SAMD9L), located on chromosome 7q, cause a multisystem disorder characterized by bone marrow failure, immunodeficiency and variable neurological involvement. Disease evolution is frequently shaped by somatic genetic rescue (SGR), most commonly through monosomy 7,
Hadjer Dellal, Roman Klifa, Lise Larcher, Marie Passet, Tristan Celse, Laetitia Gouas, Maud Tusseau, AURAGEN Consortium, Alexis Praga, Virginie Bernard, Mathieu Fusaro   +10 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Epidemiological, Clinical and Allergic Profile of Patients With Dyshidrotic Eczema (Acute and Recurrent Vesicular Dermatitis): Evaluation of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy (REIDAC)

Contact Dermatitis, EarlyView.
In this exploratory analysis, dyshidrotic eczema demonstrated a distinct sensitisation pattern compared with non‐dyshidrotic hand eczema. The lower proportion of clinically relevant reactions amongst positive patch tests suggests a multi‐factorial and not exclusively allergic background.
Araceli Sánchez‐Gilo, Enrique Gómez de la Fuente, Ana M. Giménez‐Arnau, Juan Francisco Silvestre‐Salvador, Pedro Mercader‐García, Tatiana Sanz‐Sánchez, Violeta Zaragoza‐Ninet, Susana Córdoba‐Guijarro, Javier Miquel‐Miquel, Ricardo González‐Pérez, Inmaculada Ruiz‐Gonzalez, Esther Serra‐Baldrich, José Manuel Carrascosa‐Carrillo, Francisco Javier Ortiz de Frutos, Mercedes Rodríguez‐Serna, María Elena Gatica‐Ortega, Carmen Paredes‐Suárez, Francisco J. Navarro‐Triviño, Pablo Chicharro, María Antonia Pastor‐Nieto, Marta Andreu Barasoain, José‐Juan Pereyra‐Rodríguez, Gemma Melé‐Ninot, Paloma Sánchez‐Pedreño Guillén, Marta Elosua‐González, Miguel Ángel Descalzo, Ignacio García‐Doval, Raquel Barba‐Martín, Leopoldo Borrego   +28 more
wiley   +1 more source

Cyclophosphamide is associated with long‐term treatment‐free remission in patients with pemphigus

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objective Pemphigus treatment has seen significant advancements, yet long‐term remission remains a challenge. Comparative data on the long‐term effectiveness of available therapies are limited. We compared 10‐year relapse rates in pemphigus patients treated with azathioprine or cyclophosphamide plus high‐dose IV corticosteroids ...
Bettina Santler, Simon Lüdtke, Lena Dietze, Marie Schiffmann, Dominik Straube, Jan Ehrchen   +5 more
wiley   +1 more source

[Spontaneous remission of acute myeloid leukemia with NPM1 mutation during pregnancy:a case report]. [PDF]

Zhonghua Xue Ye Xue Za Zhi
Zhang R, Zhang TS, Pan YL, Wang LL, Pang AB, Dou LP, Jing Y.   +6 more
europepmc   +1 more source

Self‐help and Volunteerism in Tanzania in the 1960s: Voluntary Labour, Nation Building and Constructing Modernity

Development and Change, EarlyView.
ABSTRACT The United Nations has declared 2026 the International Year of Volunteers for Sustainable Development. Against that backdrop, this article examines the experience of volunteerism, and specifically self‐help voluntary labour in Tanzania in the early colonial period, to explore the place of volunteerism in the construction of the post‐colonial ...
Michael Jennings
wiley   +1 more source

Seizures in children with Dravet syndrome in extreme heat: A qualitative study of parental perspectives

Developmental Medicine &Child Neurology, EarlyView.
Perspectives of parents of children with Dravet syndrome indicate that extreme heat and high temperatures exacerbate epileptic seizures, introduce new seizure triggers, and require the adoption of specific seizure‑management strategies. Abstract Aim To describe parental perspectives on how heatwaves and high ambient temperatures influence seizure ...
Angel Aledo‐Serrano, José Ángel Aibar, Domingo Palacios‐Ceña, Maria Salcedo‐Perez‐Juana, Maria Palacios‐Ceña, Simona Giorgi, Manuel Lorenzo‐Dieguez, Sanjay M Sisodiya, Cristina García‐Bravo   +8 more
wiley   +1 more source