Results 81 to 90 of about 1,858,377 (322)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

Gamma oscillation in functional brain networks is involved in the spontaneous remission of depressive behavior induced by chronic restraint stress in mice

BMC Neuroscience, 2016
BackgroundDepression is one of the most prevalent mood disorders, and is known to be associated with abnormal functional connectivity in neural networks of the brain.
Arshi Khalid, Byung Sun Kim, Bo Am Seo, S. Lee, Keun-Hwa Jung, K. Chu, Sang-Kun Lee, D. Jeon   +7 more
semanticscholar   +1 more source

Spontaneous remission of hepatocellular carcinoma without any treatment [PDF]

, 2016
Hepatocellular carcinoma (HCC) is a major leading cause of cancer death in Taiwan. The prognosis will be fatal without treatment. However, about 80 cases of the rare phenomenon of spontaneous remission of HCC have been reported in the English literature ...
Huang, Zhen-Yi, Wu, Cheng-Chung, Shao-Ciao Luo, Zhen-Yi Huang, Cheng-Chung Wu, Luo, Shao-Ciao, Shao-Bin Jheng, Jheng, Shao-Bin   +7 more
core   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML

Case Reports in Hematology, 2016
Spontaneous remission (SR) of acute myeloid leukemia (AML) is a very rare phenomenon. AML characterized by FLT3 internal tandem duplication (FLT3 ITD) is typically associated with an aggressive clinical course with rapid progression, relapse, and short ...
P. Vachhani, J. Mendler, A. Evans, George Deeb, P. Starostik, P. Wallace, E. Wang   +6 more
semanticscholar   +1 more source

T‐prolymphocytic leukaemia with spontaneous remission [PDF]

British Journal of Haematology, 2000
T‐prolymphocytic leukaemia (T‐PLL) is a rare dis‐order with a poor prognosis. A 69‐year‐old man was diagnosed as having a small‐cell variant of T‐PLL according to the French–American–British classification by haematological, immunological and ultrastructural studies, although the cells had a CD7− phenotype and no chromosomal abnormality.
T, Shichishima, M, Kawaguchi, T, MacHii, R, Matsuoka, K, Ogawa, Y, Maruyama   +5 more
openaire   +2 more sources

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Long‐term outcome of cats with acquired myasthenia gravis without evidence of a cranial mediastinal mass

Journal of Veterinary Internal Medicine, 2020
Background Acquired myasthenia gravis (AMG) is increasingly recognized in cats, yet information regarding the natural history of the disease, treatment, and outcome including occurrence of immune and spontaneous remission remains limited.
Thomas Mignan, Laurent Garosi, Mike Targett, Mark Lowrie   +3 more
doaj   +1 more source

Clonal Replacement Underlies Spontaneous Remission in Paroxysmal Nocturnal Haemoglobinuria

British Journal of Haematology, 2016
Casella, J.F., King, A.A., Barton, B., White, D.A., Noetzel, M.J., Ichord, R.N., Terrill, C., Hirtz, D., McKinstry, R.C., Strouse, J.J., Howard, T.H., Coates, T.D., Minniti, C.P., Campbell, A.D., Vendt, B.A., Lehmann, H. & Debaun, M.R.
D. Babushok, Natasha L. Stanley, Hongbo M Xie, Hugh Huang, A. Bagg, Timothy S. Olson, M. Bessler   +6 more
semanticscholar   +1 more source