Results 81 to 90 of about 149,022 (261)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying in-market application of Pelargonium root extract EPs 7630 for the treatment of COVID-19: analysis of pharmacovigilance data

Frontiers in Pharmacology
Introduction: Phytopharmaceutical products are successfully used for acute respiratory infections and may therefore be promising candidates for adjuvant symptomatic treatment of COVID-19.
Fathi Abdul Malek, Petra Funk
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

A real-world data analysis of ocular adverse events linked to anti-VEGF drugs: a WHO-VigiAccess study

Frontiers in Pharmacology
IntroductionVascular endothelial growth factor (VEGF) is key to wet age-related macular degeneration (wAMD). Anti-VEGF drugs are the main treatment in clinics.
Chen Li, Yicheng Lu, Ziyue Song, Yueqi Liu   +3 more
doaj   +1 more source

Otogenic Spontaneous pneumocephalus: case report

Brazilian Journal of Otorhinolaryngology, 2013
PhD, Medicine (Professor, FMRP-USP).Send correspondence to: Miguel Angelo Hyppolito. Av. Bandeirantes, no 3900, 12o andar. Monte Alegre. Ribeirao Preto - SP. Brazil. CEP: 14048-900.Medical School of Ribeirao Preto - University of Sao Paulo - University Hospital (FMRP - USP).FAEPA - HCRP - FMRP-USP.Paper submitted to the BJORL-SGP (Publishing Management
Rabello, Fabio Augusto, Massuda, Eduardo Tanaka, de Oliveira, Jose Antonio Apparecido, Hyppolito, Miguel Angelo   +3 more
openaire   +2 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Enhanced knowledge of spontaneous reporting with structured educational programs in Korean community pharmacists: a cross-sectional study

BMC Medical Education, 2017
Background While spontaneous reporting (SR) is one of the important public health activities for community pharmacists to guard patients’ safety, very few studies examined educational activities and its effects on knowledge about the SR system in Korea ...
Yun Mi Yu, Euni Lee
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Spontaneous Diaphragmatic Hernia: A Case Report

Journal of Academic Emergency Medicine, 2014
Although acquired diaphragmatic rupture is often associated with trauma, rarely it may be spontaneous (atraumatic). Spontaneous diaphragmatic rupture is one of the rarest thoracoabdominal emergencies, and is harder to detect in patients without visceral damage. Diagnosis may be delayed by several months or even years.
KOZACI, NALAN, BALKAN, ERKAN, KURTOĞLU ÇELİK, GÜLHAN, TANRIVERDİ, FATİH, İÇME, FERHAT, VURAL, SEVİLAY   +5 more
openaire   +3 more sources