A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. [PDF]
, 2019 Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer.
Ashworth, Alan +4 more
core +2 more sources
BMC Pediatrics, 2023 Background Sacrococcygeal teratomas (SCTs) are the most common congenital neoplasm and often require resection soon after birth. There are rare reports of cardiac arrest during surgery due to manipulation of the tumor triggering secondary necrosis and ...
Aditi Dey +5 more
doaj +1 more source
Spontaneous γH2AX Foci in Human Solid Tumor-Derived Cell Lines in Relation to p21WAF1 and WIP1 Expression. [PDF]
, 2015 Phosphorylation of H2AX on Ser139 (γH2AX) after exposure to ionizing radiation produces nuclear foci that are detectable by immunofluorescence microscopy.
Andrais, Bonnie +5 more
core +2 more sources
Fatal tumor lysis syndrome in a patient with metastatic gastric adenocarcinoma
Autopsy and Case Reports, 2021 Tumor lysis syndrome is a well-characterized and potentially deadly complication of spontaneous or treatment-related tumor destruction, and it is most commonly associated with hematologic malignancies.
Robin Moiseff +2 more
doaj
Postoperative hyperphosphatemia significantly associates with adverse survival in colorectal cancer patients [PDF]
, 2013 BACKGROUND: Hyperphosphatemia has been implicated in the development and treatment of various cancers. However, whether it can be used as a direct prognostic marker of colorectal cancer (CRC) has remained unexplored.
Guiles, Fran +8 more
core +1 more source
A Case of Spontaneous Tumor Lysis After Pathologic Femur Fracture in Squamous Cell Lung Cancer
Journal of Investigative Medicine High Impact Case Reports, 2023 Tumor lysis syndrome (TLS) occurs when large numbers of tumor cells lyse and release their contents, causing electrolyte derangements and renal injury. It is an uncommon complication of solid tumors and occurs most commonly after cytotoxic therapy rather
Jacqueline Causbie MD +2 more
doaj +1 more source
Spontaneous Tumor Lysis Syndrome in an Infant: A Case Report [PDF]
Indian Journal of Clinical Biochemistry, 2015 Tumor lysis syndrome has been observed in patients with malignancies with high cellular burden and high cell turnover, tumor sensitive to therapy, especially after initiating medical treatment. It very rarely occurs spontaneously. The case described here is of 6 months male infant who presented with fever since 1 month and loose stools associated with ...
Mamatha T, Shenoy +4 more
openaire +2 more sources
Spontaneous tumor lysis syndrome in colon cancer: a case report and literature review
Clinical Case Reports, 2017 Key Clinical Message Although tumor lysis syndrome is well described, it is rarely seen or suspected in solid malignancies. Early recognition of this entity is paramount in reducing morbidity and mortality.
David Sommerhalder +3 more
doaj +1 more source
Tumor lysis syndrome developing intraoperatively
Journal of Anaesthesiology Clinical Pharmacology, 2011 Tumor lysis syndrome is a potentially life threatening condition which is most commonly encountered in patients being treated with chemotherapy. We report a case of spontaneous tumor lysis syndrome that developed intraoperatively in a patient with ...
Ankur Verma +3 more
doaj +1 more source
Polyfunctional Melan-A-specific tumor-reactive CD8+ T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS [PDF]
, 2016 The identification of activation pathways linked to anti-tumor T-cell polyfunctionality in long surviving patients is of great relevance in the new era of immunotherapy.
Belinda, Palermobc +7 more
core +1 more source