Results 81 to 90 of about 14,329 (134)

Mitochondrial NADK2‐dependent NADPH controls tau oligomer uptake in human neurons

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Reduced brain energy metabolism, mitochondria dysfunction, and extracellular tau oligomer buildup characterize Alzheimer's disease (AD), but how these phenomena cooperatively promote neurodegeneration is poorly understood. We now report that tau oligomers (TauOs) pathologically coordinate mitochondrial metabolism with increased ...
Evelyn Pardo, Taylor Kim, Horst Wallrabe, Kristine E. Zengeler, Vijay Kumar Sagar, Garnett Mingledorff, Xuehan Sun, Ammasi Periasamy, John R. Lukens, George S. Bloom, Andrés Norambuena   +10 more
wiley   +1 more source

OGFRL1 Deficiency Causes Chronic Recurrent Multifocal Osteomyelitis Via Pathologic Osteoclastogenesis, With Therapeutic Response to Tumor Necrosis Factor Inhibitor

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1318-1326, June 2026.
Objective To verify the pathogenesis of the opioid growth factor receptor like‐1 (OGFRL1) loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a patient with chronic recurrent multifocal osteomyelitis (CRMO) and to investigate the underlying mechanism.
Wen Xiong, Yusha Wang, Tingyan He, Jinjian Fu, Ying Luo, Jinbo Wang, Jun Wang, Xiaomin Yu, Qing Zhou, Jun Yang   +9 more
wiley   +1 more source

Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases

Case Reports in Critical Care, 2017
Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers.
Vivek Alaigh, Debapriya Datta
doaj   +1 more source

Ophiopogonin D Mediates Therapeutic Effects on Primary Sjögren's Syndrome by Modulating Gut Microbiota and Metabolite Profiles

Biomedical Chromatography, Volume 40, Issue 6, June 2026.
ABSTRACT This study aimed to investigate the mechanism of ophiopogonin D (OD) in treating primary Sjögren's syndrome (pSS) through integrated analysis of gut microbiota and metabolomics. Non‐obese diabetic/LtJ mice, a well‐established pSS model, were used as the model group and treated with OD or hydroxychloroquine.
Fengtao Pang, Xueyan Shan, Yi Kong, Xiaopo Tang   +3 more
wiley   +1 more source

Clinical Diagnosis and Treatment of Ruptured Renal Artery Aneurysm During Pregnancy: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Rupture of renal artery aneurysm during pregnancy (PSRRAA) is a life‐threatening emergency that can lead to adverse outcomes for both the mother and the fetus. This paper reports a case of right renal artery aneurysm (RAA) rupture in a 32‐year‐old pregnant woman at 37 weeks of gestation, and discusses the clinical diagnosis and treatment of ...
SuFang Qiu, Yao Xiao, Yan Chen, Minglin Zhong   +3 more
wiley   +1 more source

Spontaneous tumor lysis syndrome in a patient with metastatic prostate cancer

Molecular and Clinical Oncology, 2017
Tumor lysis syndrome (TLS) is a life-threatening oncological emergency, with most cases occurring in hematological malignancies following the initiation of treatment. However, on rare occasions, TLS may occur in solid tumors as well. In the present case study, the case is reported of a 56-year-old African-American man who presented with a recent ...
Serling-Boyd, Naomi, Quandt, Zoe, Allaudeen, Nazima   +2 more
openaire   +5 more sources

Spontaneous Tumor Lysis Syndrome Secondary to Small-Cell Neuroendocrine Carcinoma of Unknown Origin: A Rare Case Report and Literature Review

Case Reports in Oncological Medicine, 2019
Spontaneous tumor lysis syndrome (STLS), in the absence of prior chemo or radiation therapy, is rare with solid tumors. Here, we present a case of STLS secondary to a small-cell neuroendocrine tumor of unknown origin in a 66-year-old female patient who ...
Phyo Thazin Myint, Hifza Waheed Butt, Taha Alrifai, Carlos Marin   +3 more
doaj   +1 more source

Fatal peripheral T-cell lymphoma presenting as hypereosinophilia and spontaneous tumor lysis syndrome: A rare case report

Indian Journal of Allergy Asthma and Immunology, 2018
Peripheral T-cell lymphomas (TCLs) are a heterogeneous group of aggressive, uncommon forms of T-cell or natural killer cell-derived non-Hodgkin's lymphomas.
Majed B Momin, Abhijeet Ingle, G Vamshi Krishna Reddy, Anamika Aluri, B Saroj Kumar Prusty   +4 more
doaj   +1 more source

Spontaneous tumor lysis syndrome in a patient with cholangiocarcinoma.

Journal of gastrointestinal oncology, 2014
Tumor lysis syndrome (TLS) is a potentially deadly complication of tumors or their treatment. This syndrome consists of a constellation of laboratory parameters such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia and clinical complications such as seizures, acute renal insult, cardiac dysrhythmias and death.
Alaa M, Ali, Aram, Barbaryan, Teresita, Zdunek, Maliha, Khan, Prakruthi, Voore, Aibek E, Mirrakhimov   +5 more
openaire   +1 more source

A Unique Case of Acute Promyelocytic Leukemia with Disseminated Intravascular Coagulation and Spontaneous Tumor Lysis Syndrome

Cyprus Journal of Medical Sciences
Acute promyelocytic leukemia (APL) is a rare and specific subtype of acute myeloid leukemia involving characteristic genetic translocations and the accumulation of abnormal promyelocytes.
Amin A. Alamin, Amna F. Bashir, Imad A. Mohamed   +2 more
doaj   +1 more source