Results 81 to 90 of about 546,299 (291)

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

A Single Lineage of Hepatitis E Virus Causes Both  Outbreaks and Sporadic Hepatitis in Sudan

Viruses, 2016
Few studies have reported sporadic hepatitis E virus (HEV) infections during non‐outbreak periods in Africa. In this study, the prevalence of HEV infection in Sudan was investigated in 432 patients with acute hepatitis from 12 localities in North ...
Adel Hussein Elduma, Mai Mohammed Adam Zein, Marie Karlsson, Isam M.E. Elkhidir, Heléne Norder   +4 more
doaj   +1 more source

Dynamics of the middle atmosphere in winter (Dynamics). Interrelation between the different variations of turbulent diffusion and ionospheric absorption originating in the middle atmosphere [PDF]

The turbulent diffusion coefficient was computed from the parameters of sporadic E layers using the wind shear theory of midlatitude sporadic E and models of the ionosphere as well as that of the neutral upper atmosphere.
Bencze, P.
core   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

Concept of Sporadic E Monitoring Using Space-Based Low Power Multiple Beacon-Systems

Atmosphere
Current monitoring systems to detect sporadic E use ground-based setups, ionosondes, and the network of GNSS satellites in order to assess the phenomenon of sporadic E.
Jurgen Vanhamel, Marc Berwaerts, Stefano Speretta, Sevket Uludag   +3 more
doaj   +1 more source

Observations of the Electrodynamical Ties Between Sporadic E and the Plasmasphere

Earth and Space Science, 2020
A joint investigation was conducted of coherent backscatter radar observations of irregularities within the E and F regions and tomographic mapping of corotating plasmaspheric irregularities (CPIs) near Japan and the American northwest from June 2018 ...
J. F. Helmboldt
doaj   +1 more source

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

Investigation into the earliest generation of medium-scale traveling ionospheric disturbances with electrodynamic signatures using dense GNSS observations over Japan

Earth, Planets and Space
Understanding the earliest formation stages of medium-scale traveling ionospheric disturbances (MSTIDs) with electrodynamic signatures (commonly referred to as nighttime MSTIDs) is essential for comprehending their full development.
Weizheng Fu, Yuichi Otsuka, Tatsuhiro Yokoyama, Zezhong Li, Mamoru Yamamoto, Michi Nishioka, Hidekatsu Jin, Keisuke Hosokawa, Claudia Stolle   +8 more
doaj   +1 more source

The Comprehensive Study of Low Thermospheric Sodium Layers during the 24th Solar Cycle

Atmosphere, 2020
The low thermospheric sodium layer (LTSL) is the separate sodium atom layer above 105 km. Based on 11,607 h of lidar observations from Yanqing (40.5° N, 116.0° E) from 2010 to 2016, we found 38 LTSLs wherein the peak densities were more than ...
Yuchang Xun, Guotao Yang, Jihong Wang, Lifang Du, Zelong Wang, Jing Jiao, Xuewu Cheng, Faquan Li, Xu Zou   +8 more
doaj   +1 more source

Correlating familial Alzheimer’s disease gene mutations with clinical phenotype [PDF]

, 2010
Alzheimer’s disease (AD) causes devastating cognitive impairment and an intense research effort is currently devoted to developing improved treatments for it.
Rossor, M.N., Ryan, N.S.
core   +1 more source