Results 41 to 50 of about 139,585 (296)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Study of height-spread sporadic-E layers observed in the South American Magnetic Anomaly

Frontiers in Astronomy and Space Sciences
Spread echoes from the E-region observed in ionograms obtained at high latitudes are generally classified as auroral sporadic-E (Esa) layers. These layers have also been detected in nighttime ionograms collected at some ionospheric stations in the South ...
Juliano Moro, Juliano Moro, Jiyao Xu, José Valentin Bageston, Lígia Alves da Silva, Lígia Alves da Silva, Laysa Cristina Araújo Resende, Laysa Cristina Araújo Resende, Clezio Marcos De Nardin, Vânia Fátima Andrioli, Vânia Fátima Andrioli, Angela Machado Santos, Angela Machado Santos, Giorgio Arlan da Silva Picanço, Hui Li, Liu Zhengkuan, Chi Wang, Nelson Jorge Schuch   +17 more
doaj   +1 more source

Horizontal structure of convergent wind shear associated with sporadic E layers over East Asia

Earth and Planetary Physics, 2023
At present, the main detection instruments for observing sporadic E (Es) layers are ground-based radars, dense networks of ground-based global navigation satellite system (GNSS) receivers, and GNSS radio occultation, but they cannot capture the whole ...
LiHui Qiu, Xian Lu, Tao Yu, Yosuke Yamazaki, HuiXin Liu, Yang-Yi Sun, HaoNan Wu, XiaoMin Zuo, XiangXiang Yan, Yan Yu, YiFan Qi   +10 more
doaj   +1 more source

Deep convolutional and LSTM recurrent neural networks for multimodal wearable activity recognition [PDF]

, 2016
Human activity recognition (HAR) tasks have traditionally been solved using engineered features obtained by heuristic processes. Current research suggests that deep convolutional neural networks are suited to automate feature extraction from raw sensor ...
Alsheikh, Daniel Roggen, Dauphin, Dieleman, Francisco Ordóñez, Gers, Japkowicz, Karpathy, LeCun, Ng, Pigou, Sermanet   +11 more
core   +2 more sources

Evaluation of E Layer Dominated Ionosphere Events Using COSMIC/FORMOSAT-3 and CHAMP Ionospheric Radio Occultation Data [PDF]

, 2020
At certain geographic locations, especially in the polar regions, the ionization of the ionospheric E layer can dominate over that of the F2 layer. The associated electron density profiles show their ionization maximum at E layer heights between 80 and ...
Hoque, Mohammed M., Jakowski, Norbert, Kamal, Sumon, Wickert, Jens   +3 more
core   +2 more sources

Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis.
Philipp Arndt, Eya Khadhraoui, Sebastian J. Müller, Katja Neumann, Hendrik Mattern, Sven G. Meuth, Valentina Perosa, Andreas Charidimou, Stefanie Schreiber   +8 more
wiley   +1 more source

Von Economo Neuron Loss in Frontotemporal Dementia: A Meta‐Analysis of Neuropathological Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Von Economo neurons (VENs) have been reported to be vulnerable to neurodegeneration in frontotemporal dementia (FTD), particularly the behavioral variant (bvFTD), but these findings have not been systematically assessed across independent brain banks.
Daniel Talmasov, Alexander F. Santillo, Patrick R. Hof   +2 more
wiley   +1 more source

Thunderstorms and Sporadic E Layer Ionisation

MAUSAM, 1957
The paper describes the results of vertical P'-f recordings of ionospheric reflections carried out during the passage of thunderstorms over Ahmedabad. The thunderstorms were found to be accompanied by an increase in sporadic E ionisation as shown by a rise in the maximum frequency of the Ea or an increase in the intensity of reflection from Es.  &
openaire   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source