Potential therapeutic targeting of BKCa channels in glioblastoma treatment
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Prevalence of meeting youth physical activity guidelines across income, sex, urbanicity, and sport participation: 2022-2023 National Survey of Children's Health (NSCH). [PDF]
Johnson A.
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Sport participation after unicompartmental knee arthroplasty: High return rates independent of implant design or technique, a systematic review and meta-analysis. [PDF]
Cerasoli T +6 more
europepmc +1 more source
CHILD ABUSE IN SPORTS: A STUDY ON THE AWARENESS LEVELS OF FACULTY OF SPORT SCIENCES STUDENTS
Melis Seray Özden +2 more
openalex +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The impact of badminton participation on attention control in college students: the mediating role of flow experience. [PDF]
Ren Y, Chen W, Peng B, Yu L, Kong M.
europepmc +1 more source

