Results 301 to 310 of about 2,348,284 (385)

Temporal Associations Between Sport Participation, Dropout from Sports, and Mental Health Indicators: A Two-Year Follow-Up Study. [PDF]

Behav Sci (Basel)
Säfvenbom R, Haugen T, Sandsaunet Ulset V, Ivarsson A.   +3 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Female, woman and/or girl Athlete Injury pRevention (FAIR) practical recommendations: International Olympic Committee (IOC) consensus meeting held in Lausanne, Switzerland, 2025. [PDF]

Br J Sports Med
Crossley KM, Whittaker JL, Patterson B, Shill IJ, Heming EE, Bullock GS, Dijkstra HP, Donaldson A, McKay CD, Mountjoy M, Møller M, Owoeye OBA, Räisänen AM, Schulz JM, Blauwet C, McHugh TL, Mosler AB, Myklebust G, Palmer D, Ross A, Schneider KJ, Thornton J, Chintoh A, Verhagen E, Emery C.   +24 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Identifying Prevention Strategies for Ice Hockey Laceration Injuries. [PDF]

Sports Health
DeLong RN, Brookhart B, Martin C, Shore E, Kucera KL, Register-Mihalik JK.   +5 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A study on the nutritional intake status and nutrition awareness of Korean national athletes with disabilities. [PDF]

Phys Act Nutr
Kim JY, Kim SY, Lee SM, An YH.
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Sportive agoraphobia: scale development and validation. [PDF]

Front Psychol
Celebi M, Pehlivan NN, Arici M, Ayrancı M, Tosun MI, Efdal A, Sarikabak M, Markovic M.   +7 more
europepmc   +1 more source