Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Rediscovery of animality in the concept of sport: a posthuman perspective. [PDF]
Front Sports Act LivingSakamoto T, Sato Y.
europepmc +1 more source
Place Attachment of Fans and Sports Spectator Behavior in Professional Sports
Journal of Japan Society of Sports Industry, 2010 openaire +2 more sources
Place, Sport and Globalization: Making sense of the marca Barça
Treballs de la Societat Catalana de Geografia, 2006 The case of Football Club (FC) Barcelona provides a compelling case for examining the impact of globalization on the place/identity role of football clubs. FC Barcelona has deep historical connections to Barcelona and Catalonia. These connections were de-emphasized by the clubs leadership under Josep Lluís Núñez (1978-2000) and Joan Gaspart (2000-2003)
openaire +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Motivations of Sports Volunteers at Mass Endurance Events: A Case Study of Poznan. [PDF]
Sports (Basel)Michalska M, Grajek M, Rozmiarek M.
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Athlete maltreatment in sport: Protocol for a scoping review. [PDF]
PLoS OneBrown DM +4 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Examining the relationship between sport, physical activity and "Green Attitudes" among students in different university programmes. [PDF]
Front Sports Act LivingMoravecz M +3 more
europepmc +1 more source