Results 71 to 80 of about 101,931 (287)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Normative Ethics and Sport: A Moral Manifesto

open access: yesPhysical Culture and Sport: Studies and Research, 2014
This article constitutes a strictly cognitive and completely non-ideological moral (or rather, amoral) manifesto that makes no value judgments. The article concerns relationships that, according to sport enthusiasts with varying levels of competence ...
Kosiewicz Jerzy
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Defamiliarizing heavy-contact sports: A critical examination of rugby, discipline, and pleasure [PDF]

open access: yes, 2009
Pleasure can be regarded as a productive force in the constitution of the social sig-nificance of sport and desiring sport subjects. The organization and use of sport plea-sure has been a relatively marginalized topic of examination.
Pringle, Richard
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Healthy sport for healthy girls? The role of parents in preventing sexual abuse in sport. [PDF]

open access: yes, 1998
Sexual abuse has only recently been recognised as a problem within sport (Brackenridge 1994) and, as yet, little is known about the contexts in which girls might be at greater or lesser risk of experiencing such crimes.
Brackenridge, CH
core   +1 more source

Rethinking places for sport in the Anthropocene

open access: yesInternational Review for the Sociology of Sport
Anthropogenic climate change has profound effects globally. If the Anthropocene signifies the decline of nature as we once knew it, how might this transformation affect sporting activities conducted in natural environments? This scenario necessitates a renegotiation not only of the future of sports but also of humanity's shared history and the ...
Peter Carlman   +1 more
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Playing with the Rules: Influences on the Development of Regulation in Sport [PDF]

open access: yes, 2007
Sport today is a rule-governed practice: constitutive rules, both prescriptive and proscriptive, define required equipment and facilities as well as setting the formal rules of play; auxiliary rules specify and control eligibility: and regulatory rules ...
Vamplew, Wray
core   +1 more source

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