Results 61 to 70 of about 26,692 (306)

The sport business industry in the twenty-first century

open access: yes, 2018
Sport has become a significant global industry. As Westerbeek and Smith (2003) point out and is discussed in this collection, the sport market is a truly global market driven by the universal nature of sport competition. The worldwide appeal of sport and
Riot, Caroline   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Obstacles of Attracting Sponsorship in the Sport Industry of East Azarbaijan Province [PDF]

open access: yesمدیریت بهره وری, 2009
Sponsorship has become a vital part of funding for a wide range of sporting, artistic, and social events. Sponsorship has been increasing as an element of marketing communications. However, there are obstacles to attracting sponsors in the sport industry.
Mir Hassan Seyyed Ameri   +3 more
doaj  

Corruption in Australian sport [PDF]

open access: yes, 2015
Examines some of the events that have affected the integrity of Australian sport between 2009–13 to describe the way in which corruption has manifested, the environment that has engendered the corrupt behaviour and the extent to which these incidents ...
Samantha Bricknell
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

ECONOMETRIC MODELS IN RESEARCHING THE IMPACT OF SPORT INDUSTRY ON SOCIAL AND ECONOMIC DEVELOPMENT OF THE REGION (illustrated by the Republic of Mordovia)

open access: yesВестник Российского экономического университета имени Г. В. Плеханова, 2017
The article offers a critical analysis of overseas and home research dealing with the impact of physical culture and sports and arrangement of big sport events on economic and social development of the country. It is pointed out that special attention in
Elena V. Zarova, Il'ya V. Solntsev
doaj   +1 more source

Developing the Malaysian sport industry: A programme of capacity building research. Developing the capacity of National Sport Associations

open access: yes, 2011
First paragraph: An analysis of National Sport Associations (NSAs) was carried out using the Readiness Assessment Tool developed by Robinson and Minikin (2011).
Robinson, Leigh, Minikin, Brian
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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