Results 111 to 120 of about 1,030,909 (264)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Dietary intake, nutrition knowledge, and behavior in youth team sport athletes: a scoping review and call to advance research and practice

Journal of the International Society of Sports Nutrition
Background Youth team sport athletes face unique nutritional challenges due to the combined demands of growth, development and exercise. This scoping review systematically mapped the literature on dietary intake, nutrition knowledge, education ...
Neil Irwin, Ciarán Ó Catháin, Cormac Ward, David T. Kelly   +3 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Riding with the flow: study on intrinsic motivation, dispositional flow, and sensation seeking among Italian motorcycle racers

Frontiers in Sports and Active Living
BackgroundThere is a limited body of research investigating psychological dimensions involved in motorcycle racing. Exploring intrinsic motivation becomes crucial since it is associated with high performance and sport persistence.
Paolo Mancin, Maria Stefania Ionel, Silvia Cerea, Silvia Cerea, Eleonora F. M. Riva, Martina Rapisarda, Marta Ghisi, Marta Ghisi   +7 more
doaj   +1 more source

Persistence of Practicing Sports Among Young People: A Comparative Evaluation

Bulletin of the Transilvania University of Braşov. Series IX: Sciences of Human Kinetics
In the current context, young people face an increasingly limited availability of time to manage all the activities they propose, and this temporal restriction also influences their habits regarding physical activity and practicing sports. The benefits that physical activities have on the mental health of young people are manifested in various aspects,
I.E. Sandu, M. Dragomir
openaire   +2 more sources

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

“But my horse is well cared for”: A qualitative exploration of cognitive dissonance and enculturation in equestrian attitudes toward performance horses and their welfare

Animal Welfare
There is concern amongst the public, equestrians, animal welfare organisations, and horse-sport governing bodies regarding the welfare of performance horses, but equestrian culture appears slow to change.
Erica Cheung, Daniel Mills, Beth Ann Ventura   +2 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Adherence, persistence, and medication discontinuation in patients with attention-deficit/hyperactivity disorder – a systematic literature review

Neuropsychiatric Disease and Treatment, 2014
Kavita Gajria,1 Mei Lu,2 Vanja Sikirica,1 Peter Greven,3,4 Yichen Zhong,2 Paige Qin,2 Jipan Xie2 1Global Health Economics, Outcomes Research and Epidemiology, Shire, Wayne, PA, USA; 2Health Economics and Outcomes Research, Analysis Group, Inc., Boston ...
Gajria K, Lu M, Sikirica V, Greven P, Zhong Y, Qin P, Xie J   +6 more
doaj