Results 81 to 90 of about 1,030,909 (264)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Inside-Out and Outside-In: Dual Pathways of Grit Development in Youth Powerlifting

Youth
Background: Grit is often celebrated as a predictor of youth success in sport, but little is known about how it develops over time through social and relational contexts.
Chandreshan Ravichandren, Haslinda Abdullah, Mursyid Arshad   +2 more
doaj   +1 more source

The high end of toy motivation in dogs: developmental predictors and relevance for sport and working dogsThe high end of toy motivation in dogs: developmental predictors and relevance for sport and working dogs [PDF]

Royal Society Open Science
Toy-directed play motivation varies significantly among domestic dogs. In some individuals, it reaches such exceptional levels that it exhibits phenomenological parallels with behavioural addictions. This study investigated demographic, developmental and
Alja Mazzini, Stefanie Riemer
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Determinants and Reasons for Dropout in Swimming —Systematic Review

Sports, 2017
The present research aims to systematically review the determinants and reasons for swimming dropout. The systematic review was conducted through electronic searches on the Web of Knowledge and PsycInfo databases from 2 February to 29 July 2015, using ...
Diogo Monteiro, Luis Cid, Daniel Almeida Marinho, João Moutão, Anabela Vitorino, Teresa Bento   +5 more
doaj   +1 more source

Persistent Disruption of Brain Connectivity after Sports-Related Concussion in a Female Athlete

Journal of Neurotrauma, 2019
Structural and functional connectivity (FC) after sports-related concussion (SRC) may remain altered in adolescent athletes despite symptom resolution. Little is known, however, about how alterations in structural connectivity and FC co-present in female athletes whose symptom recovery tends to be prolonged.
Elisabeth A, Wilde, Mary R, Newsome, Summer D, Ott, Jill V, Hunter, Pramod, Dash, John, Redell, Matthew, Spruiell, Marlene, Diaz, Zili D, Chu, Naomi, Goodrich-Hunsaker, JoAnn, Petrie, Ruosha, Li, Harvey, Levin   +12 more
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

ACL Rehabilitation Plateaus Across Athlete Populations: Two Case Reports and a Clinical Framework for Identifying Functional Stagnation

International Journal of Sports Physical Therapy
# Background and Purpose Anterior cruciate ligament (ACL) rehabilitation typically follows a structured protocol for progressive recovery. However, not all subjects achieve expected functional milestones, despite adherence.
E. Ram Kumar Sr., Suvathi R Sr., Jenish J. Khristi, K. Mathipriya, R. Nivetha, Aabitha Banu Ubaithullah   +5 more
doaj   +1 more source

Beyond the Jersey: Black Male College Athletes and the Construction of Self-Identity at historically White colleges and universities

Journal of Intercollegiate Sport
Drawing on the master narrative framework and strategic responsiveness to interest convergence, this qualitative study examines how Black male college athletes (BMCAs) understand and define their Black identity as male college athletes, and how ...
Joseph Herman, II, Trevor Bopp, Donald D. McAulay, Jr.   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source